In vivo kinetics of early, non-random methylome and transcriptome changes induced by DNA-hypomethylating treatment in primary AML blasts

Despite routine use of DNA-hypomethylating agents (HMAs) in AML/MDS therapy, their mechanisms of action are not yet unraveled. Pleiotropic effects of HMAs include global methylome and transcriptome changes. We asked whether in blasts and T-cells from AML patients HMA-induced in vivo demethylation an...

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Detalles Bibliográficos
Autores principales: Greve, Gabriele, Andrieux, Geoffroy, Schlosser, Pascal, Blagitko-Dorfs, Nadja, Rehman, Usama-Ur, Ma, Tobias, Pfeifer, Dietmar, Heil, Gerhard, Neubauer, Andreas, Krauter, Jürgen, Heuser, Michael, Salih, Helmut R., Döhner, Konstanze, Döhner, Hartmut, Hackanson, Björn, Boerries, Melanie, Lübbert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169639/
https://www.ncbi.nlm.nih.gov/pubmed/37024521
http://dx.doi.org/10.1038/s41375-023-01876-2

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