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Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism

Hypoparathyroidism is a relatively rare human and veterinary disease characterized by deficient or absent production of parathyroid hormone (PTH). PTH is known as a classical regulator of calcium and phosphorus homeostasis. Nevertheless, the hormone also appears to modulate immune functions. For exa...

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Autores principales: Butylina, Maria, Föger-Samwald, Ursula, Gelles, Katharina, Pietschmann, Peter, Sipos, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169642/
https://www.ncbi.nlm.nih.gov/pubmed/37180074
http://dx.doi.org/10.3389/fvets.2023.1163903
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author Butylina, Maria
Föger-Samwald, Ursula
Gelles, Katharina
Pietschmann, Peter
Sipos, Wolfgang
author_facet Butylina, Maria
Föger-Samwald, Ursula
Gelles, Katharina
Pietschmann, Peter
Sipos, Wolfgang
author_sort Butylina, Maria
collection PubMed
description Hypoparathyroidism is a relatively rare human and veterinary disease characterized by deficient or absent production of parathyroid hormone (PTH). PTH is known as a classical regulator of calcium and phosphorus homeostasis. Nevertheless, the hormone also appears to modulate immune functions. For example, increased CD4:CD8 T-cell ratios and elevated interleukin (IL)-6 and IL-17A levels were observed in patients with hyperparathyroidism, whereas gene expression of tumor necrosis factor-α (TNF-α) and granulocyte macrophage-colony stimulating factor (GM-CSF) was decreased in patients with chronic postsurgical hypoparathyroidism. Various immune cell populations are affected differently. So, there is a need for validated animal models for the further characterization of this disease for identifying targeted immune-modulatory therapies. In addition to genetically modified mouse models of hypoparathyroidism, there are surgical rodent models. Parathyroidectomy (PTX) can be well performed in rats—for pharmacological and associated osteoimmunological research and bone mechanical studies, a large animal model could be preferable, however. A major drawback for successfully performing total PTX in large animal species (pigs and sheep) is the presence of accessory glands, thus demanding to develop new approaches for real-time detection of all parathyroid tissues.
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spelling pubmed-101696422023-05-11 Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism Butylina, Maria Föger-Samwald, Ursula Gelles, Katharina Pietschmann, Peter Sipos, Wolfgang Front Vet Sci Veterinary Science Hypoparathyroidism is a relatively rare human and veterinary disease characterized by deficient or absent production of parathyroid hormone (PTH). PTH is known as a classical regulator of calcium and phosphorus homeostasis. Nevertheless, the hormone also appears to modulate immune functions. For example, increased CD4:CD8 T-cell ratios and elevated interleukin (IL)-6 and IL-17A levels were observed in patients with hyperparathyroidism, whereas gene expression of tumor necrosis factor-α (TNF-α) and granulocyte macrophage-colony stimulating factor (GM-CSF) was decreased in patients with chronic postsurgical hypoparathyroidism. Various immune cell populations are affected differently. So, there is a need for validated animal models for the further characterization of this disease for identifying targeted immune-modulatory therapies. In addition to genetically modified mouse models of hypoparathyroidism, there are surgical rodent models. Parathyroidectomy (PTX) can be well performed in rats—for pharmacological and associated osteoimmunological research and bone mechanical studies, a large animal model could be preferable, however. A major drawback for successfully performing total PTX in large animal species (pigs and sheep) is the presence of accessory glands, thus demanding to develop new approaches for real-time detection of all parathyroid tissues. Frontiers Media S.A. 2023-04-26 /pmc/articles/PMC10169642/ /pubmed/37180074 http://dx.doi.org/10.3389/fvets.2023.1163903 Text en Copyright © 2023 Butylina, Föger-Samwald, Gelles, Pietschmann and Sipos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Butylina, Maria
Föger-Samwald, Ursula
Gelles, Katharina
Pietschmann, Peter
Sipos, Wolfgang
Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
title Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
title_full Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
title_fullStr Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
title_full_unstemmed Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
title_short Challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
title_sort challenges in establishing animal models for studying osteoimmunology of hypoparathyroidism
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169642/
https://www.ncbi.nlm.nih.gov/pubmed/37180074
http://dx.doi.org/10.3389/fvets.2023.1163903
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