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Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis
BACKGROUND: Environmental noise exposure is linked to neuroinflammation and imbalance of the gut microbiota. Promoting gut microbiota homeostasis may be a key factor in relieving the deleterious non-auditory effects of noise. This study aimed to investigate the effect of Lactobacillus rhamnosus GG (...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169735/ https://www.ncbi.nlm.nih.gov/pubmed/37180445 http://dx.doi.org/10.3389/fcimb.2023.1067367 |
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author | Li, Xiaofang Zheng, Pengfang Cao, Wa Cao, Yang She, Xiaojun Yang, Honglian Ma, Kefeng Wu, Fangshan Gao, Xiujie Fu, Yu Yin, Jiayi Wei, Fei Jiang, Shoufang Cui, Bo |
author_facet | Li, Xiaofang Zheng, Pengfang Cao, Wa Cao, Yang She, Xiaojun Yang, Honglian Ma, Kefeng Wu, Fangshan Gao, Xiujie Fu, Yu Yin, Jiayi Wei, Fei Jiang, Shoufang Cui, Bo |
author_sort | Li, Xiaofang |
collection | PubMed |
description | BACKGROUND: Environmental noise exposure is linked to neuroinflammation and imbalance of the gut microbiota. Promoting gut microbiota homeostasis may be a key factor in relieving the deleterious non-auditory effects of noise. This study aimed to investigate the effect of Lactobacillus rhamnosus GG (LGG) intervention on noise-induced cognitive deficits and systemic inflammation in rats. METHODS: Learning and memory were assessed using the Morris water maze, while 16S rRNA sequencing and gas chromatography-mass spectrometry were used to analyze the gut microbiota and short-chain fatty acid (SCFA) content. Endothelial tight junction proteins and serum inflammatory mediators were assessed to explore the underlying pathological mechanisms. RESULTS: The results indicated that Lactobacillus rhamnosus GG intervention ameliorated noise-induced memory deterioration, promoted the proliferation of beneficial bacteria, inhibited the growth of harmful bacteria, improved dysregulation of SCFA-producing bacteria, and regulated SCFA levels. Mechanistically, noise exposure led to a decrease in tight junction proteins in the gut and hippocampus and an increase in serum inflammatory mediators, which were significantly alleviated by Lactobacillus rhamnosus GG intervention. CONCLUSION: Taken together, Lactobacillus rhamnosus GG intervention reduced gut bacterial translocation, restored gut and blood-brain barrier functions, and improved gut bacterial balance in rats exposed to chronic noise, thereby protecting against cognitive deficits and systemic inflammation by modulating the gut-brain axis. |
format | Online Article Text |
id | pubmed-10169735 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101697352023-05-11 Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis Li, Xiaofang Zheng, Pengfang Cao, Wa Cao, Yang She, Xiaojun Yang, Honglian Ma, Kefeng Wu, Fangshan Gao, Xiujie Fu, Yu Yin, Jiayi Wei, Fei Jiang, Shoufang Cui, Bo Front Cell Infect Microbiol Cellular and Infection Microbiology BACKGROUND: Environmental noise exposure is linked to neuroinflammation and imbalance of the gut microbiota. Promoting gut microbiota homeostasis may be a key factor in relieving the deleterious non-auditory effects of noise. This study aimed to investigate the effect of Lactobacillus rhamnosus GG (LGG) intervention on noise-induced cognitive deficits and systemic inflammation in rats. METHODS: Learning and memory were assessed using the Morris water maze, while 16S rRNA sequencing and gas chromatography-mass spectrometry were used to analyze the gut microbiota and short-chain fatty acid (SCFA) content. Endothelial tight junction proteins and serum inflammatory mediators were assessed to explore the underlying pathological mechanisms. RESULTS: The results indicated that Lactobacillus rhamnosus GG intervention ameliorated noise-induced memory deterioration, promoted the proliferation of beneficial bacteria, inhibited the growth of harmful bacteria, improved dysregulation of SCFA-producing bacteria, and regulated SCFA levels. Mechanistically, noise exposure led to a decrease in tight junction proteins in the gut and hippocampus and an increase in serum inflammatory mediators, which were significantly alleviated by Lactobacillus rhamnosus GG intervention. CONCLUSION: Taken together, Lactobacillus rhamnosus GG intervention reduced gut bacterial translocation, restored gut and blood-brain barrier functions, and improved gut bacterial balance in rats exposed to chronic noise, thereby protecting against cognitive deficits and systemic inflammation by modulating the gut-brain axis. Frontiers Media S.A. 2023-04-26 /pmc/articles/PMC10169735/ /pubmed/37180445 http://dx.doi.org/10.3389/fcimb.2023.1067367 Text en Copyright © 2023 Li, Zheng, Cao, Cao, She, Yang, Ma, Wu, Gao, Fu, Yin, Wei, Jiang and Cui https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Li, Xiaofang Zheng, Pengfang Cao, Wa Cao, Yang She, Xiaojun Yang, Honglian Ma, Kefeng Wu, Fangshan Gao, Xiujie Fu, Yu Yin, Jiayi Wei, Fei Jiang, Shoufang Cui, Bo Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
title |
Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
title_full |
Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
title_fullStr |
Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
title_full_unstemmed |
Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
title_short |
Lactobacillus rhamnosus GG ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
title_sort | lactobacillus rhamnosus gg ameliorates noise-induced cognitive deficits and systemic inflammation in rats by modulating the gut-brain axis |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169735/ https://www.ncbi.nlm.nih.gov/pubmed/37180445 http://dx.doi.org/10.3389/fcimb.2023.1067367 |
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