Cargando…

Network pharmacology to explore the mechanism of scutellarin in the treatment of brain ischaemia and experimental verification of JAK2/STAT3 signalling pathway

Scutellarin is used to treat brain ischaemia. However, its underlying mechanism of action remains unclear. This study aimed to elucidate the potential mechanism of action of scutellarin in brain ischaemia through network pharmacology and experimental verification. The JAK2/STAT3 signalling pathway w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Qiu-Ye, Chen, Hao‑Lun, Qi, Zhi, Zhang, Xiao‑Li‑Na, Zheng, Li-Yang, Liu, Teng-Teng, Yuan, Yun, Yang, Li, Wu, Chun‑Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169761/ https://www.ncbi.nlm.nih.gov/pubmed/37160937 http://dx.doi.org/10.1038/s41598-023-33156-5

Ejemplares similares

Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis
por: Hu, Xinyu, et al.
Publicado: (2018)

Scutellarin attenuates microglia activation in experimentally induced hypoxia-ischemia brain damage by down-regulating miRNA-7036a: Scutellarin suppresses microglia mediated inflammation
por: Jia, Wenji, et al.
Publicado: (2023)

Preparation and characterization of scutellarin loaded on ultradeformable nano-liposomes scutellarin EDTMP (S-UNL-E) and in vitro study of its osteogenesis
por: Minhua, Teng, et al.
Publicado: (2022)

Network pharmacology mechanism of Scutellarin to inhibit RGC pyroptosis in diabetic retinopathy
por: Li, Na, et al.
Publicado: (2023)

Scutellarin inhibits proliferation and invasion of hepatocellular carcinoma cells via down‐regulation of JAK2/STAT3 pathway
por: Liu, Kang, et al.
Publicado: (2019)

Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats
por: Teng, Minhua, et al.
Publicado: (2022)

Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia
por: Huang, Zhe, et al.
Publicado: (2022)

Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer
por: Gao, Jia, et al.
Publicado: (2022)

Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway
por: Xu, Ming, et al.
Publicado: (2020)

Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo
por: Chang, Yuqian, et al.
Publicado: (2023)

Exploring the Antiglioma Mechanisms of Luteolin Based on Network Pharmacology and Experimental Verification
por: Huang, Renxuan, et al.
Publicado: (2021)

Integrating network pharmacology and experimental verification to explore the mechanism of puerarin against oliguria in acute alcoholism
por: Wan, Mei-Xuan, et al.
Publicado: (2022)

Network pharmacology and in vitro experimental verification to explore the mechanism of Sanhua decoction in the treatment of ischaemic stroke
por: Zhang, Wei, et al.
Publicado: (2022)

Scutellarin’s Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα
por: Li, Lin, et al.
Publicado: (2015)

Exploring the role and mechanism of Fuzi decoction in the treatment of osteoporosis by integrating network pharmacology and experimental verification
por: Li, Fudong, et al.
Publicado: (2023)

Network Pharmacology and Experimental Verification to Explore the Potential Mechanism of Yin-Huo-Tang for Lung Adenocarcinoma Recurrence
por: Liu, Dianna, et al.
Publicado: (2022)

An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
por: Dong, Ze-Xi, et al.
Publicado: (2016)

Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
por: Harel, Sivan, et al.
Publicado: (2015)

Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
por: Yin, Qianqian, et al.
Publicado: (2021)

Heat‐shock transcription factor 1 is critically involved in the ischaemia‐induced cardiac hypertrophy via JAK2/STAT3 pathway
por: Yuan, Lingyan, et al.
Publicado: (2018)

Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of asparagus against polycystic ovary syndrome
por: Xing, Jinshan, et al.
Publicado: (2023)

The involvement of JAK-STAT3 in cell motility, invasion, and metastasis
por: Teng, Yong, et al.
Publicado: (2014)

Metabolic engineering of Yarrowia lipolytica for scutellarin production
por: Wang, Yina, et al.
Publicado: (2022)

Exploring the mechanisms under Zuogui Pill’s treatment of ischemic stroke through network pharmacology and in vitro experimental verification
por: Li, Li, et al.
Publicado: (2023)

Effect of Xuefu Zhuyu Capsule on Myocardial Infarction: Network Pharmacology and Experimental Verification
por: Duan, Jinlong, et al.
Publicado: (2023)

Exploration of the effect and potential mechanism of quercetin in repairing spinal cord injury based on network pharmacology and in vivo experimental verification
por: Shen, Wenyuan, et al.
Publicado: (2023)

Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway
por: Du, Xiaohua, et al.
Publicado: (2015)

Molecular docking, network pharmacology and experimental verification to explore the mechanism of Wulongzhiyangwan in the treatment of pruritus
por: Anqi, Lyu, et al.
Publicado: (2023)

Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
por: Huang, Renxuan, et al.
Publicado: (2023)

JAK-STAT and bone metabolism
por: Li, Jiliang
Publicado: (2013)

Scutellarin Reduces Cerebral Ischemia Reperfusion Injury Involving in Vascular Endothelium Protection and PKG Signal
por: Chen, Ya-Juan, et al.
Publicado: (2021)

Systematically Investigating the Pharmacological Mechanism of Momordica grosvenori in the Treatment of Spinal Cord Injury by Network Pharmacology and Experimental Verification
por: Wang, Jiling, et al.
Publicado: (2023)

Tofacitinib Ameliorates Lipopolysaccharide-Induced Acute Kidney Injury by Blocking the JAK-STAT1/STAT3 Signaling Pathway
por: Yun, Yang, et al.
Publicado: (2021)

Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells
por: Scarno, Gianluca, et al.
Publicado: (2019)

Oral Scutellarin Treatment Ameliorates Retinal Thinning and Visual Deficits in Experimental Glaucoma
por: Zhu, Jingyuan, et al.
Publicado: (2021)

JAK-STAT pathway and myogenic differentiation
por: Jang, You-Na, et al.
Publicado: (2013)

A Study Based on Metabolomics, Network Pharmacology, and Experimental Verification to Explore the Mechanism of Qinbaiqingfei Concentrated Pills in the treatment of Mycoplasma Pneumonia
por: Liu, Zheng, et al.
Publicado: (2021)

Exploring the Mechanism of Bergamot Essential Oil against Asthma Based on Network Pharmacology and Experimental Verification
por: Feng, Siwen, et al.
Publicado: (2023)

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia
por: Yuan, Yun, et al.
Publicado: (2014)

Exercise‐induced peptide EIP‐22 protect myocardial from ischaemia/reperfusion injury via activating JAK2/STAT3 signalling pathway
por: Zhang, Li, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qaueqcjcml1qp8k6vf2r9f3h79