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Artificial Hsp104-mediated systems for re-localizing protein aggregates

Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity. To approach the role of sPQC in cellular fitness, neurodegenerative diseases and aging, we report on the construction of Hsp100-based systems...

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Detalles Bibliográficos
Autores principales:	Fischbach, Arthur, Johns, Angela, Schneider, Kara L., Hao, Xinxin, Tessarz, Peter, Nyström, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169802/ https://www.ncbi.nlm.nih.gov/pubmed/37160881 http://dx.doi.org/10.1038/s41467-023-37706-3

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