Anatomical and functional maturation of the mid-gestation human enteric nervous system

Immature gastrointestinal motility impedes preterm infant survival. The enteric nervous system controls gastrointestinal motility, yet it is unknown when the human enteric nervous system matures enough to carry out vital functions. Here we demonstrate that the second trimester human fetal enteric ne...

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Autores principales: Dershowitz, Lori B., Li, Li, Pasca, Anca M., Kaltschmidt, Julia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170115/
https://www.ncbi.nlm.nih.gov/pubmed/37160892
http://dx.doi.org/10.1038/s41467-023-38293-z
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author Dershowitz, Lori B.
Li, Li
Pasca, Anca M.
Kaltschmidt, Julia A.
author_facet Dershowitz, Lori B.
Li, Li
Pasca, Anca M.
Kaltschmidt, Julia A.
author_sort Dershowitz, Lori B.
collection PubMed
description Immature gastrointestinal motility impedes preterm infant survival. The enteric nervous system controls gastrointestinal motility, yet it is unknown when the human enteric nervous system matures enough to carry out vital functions. Here we demonstrate that the second trimester human fetal enteric nervous system takes on a striped organization akin to the embryonic mouse. Further, we perform ex vivo functional assays of human fetal tissue and find that human fetal gastrointestinal motility matures in a similar progression to embryonic mouse gastrointestinal motility. Together, this provides critical knowledge, which facilitates comparisons with common animal models to advance translational disease investigations and testing of pharmacological agents to enhance gastrointestinal motility in prematurity.
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spelling pubmed-101701152023-05-11 Anatomical and functional maturation of the mid-gestation human enteric nervous system Dershowitz, Lori B. Li, Li Pasca, Anca M. Kaltschmidt, Julia A. Nat Commun Article Immature gastrointestinal motility impedes preterm infant survival. The enteric nervous system controls gastrointestinal motility, yet it is unknown when the human enteric nervous system matures enough to carry out vital functions. Here we demonstrate that the second trimester human fetal enteric nervous system takes on a striped organization akin to the embryonic mouse. Further, we perform ex vivo functional assays of human fetal tissue and find that human fetal gastrointestinal motility matures in a similar progression to embryonic mouse gastrointestinal motility. Together, this provides critical knowledge, which facilitates comparisons with common animal models to advance translational disease investigations and testing of pharmacological agents to enhance gastrointestinal motility in prematurity. Nature Publishing Group UK 2023-05-09 /pmc/articles/PMC10170115/ /pubmed/37160892 http://dx.doi.org/10.1038/s41467-023-38293-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Dershowitz, Lori B.
Li, Li
Pasca, Anca M.
Kaltschmidt, Julia A.
Anatomical and functional maturation of the mid-gestation human enteric nervous system
title Anatomical and functional maturation of the mid-gestation human enteric nervous system
title_full Anatomical and functional maturation of the mid-gestation human enteric nervous system
title_fullStr Anatomical and functional maturation of the mid-gestation human enteric nervous system
title_full_unstemmed Anatomical and functional maturation of the mid-gestation human enteric nervous system
title_short Anatomical and functional maturation of the mid-gestation human enteric nervous system
title_sort anatomical and functional maturation of the mid-gestation human enteric nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170115/
https://www.ncbi.nlm.nih.gov/pubmed/37160892
http://dx.doi.org/10.1038/s41467-023-38293-z
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