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Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation

PURPOSE: To analyse the clinical and morphological characteristics of eyes with idiopathic epiretinal membrane (iERM) and foveal herniation (FH). METHODS: Clinical findings and OCT features of patients with iERM and FH were retrospectively analysed. Primary outcome were changes of the best-corrected...

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Autores principales: Uzel, Mehmet Murat, Gelisken, Faik, Konrad, Eva, Neubauer, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170127/
https://www.ncbi.nlm.nih.gov/pubmed/35697750
http://dx.doi.org/10.1038/s41433-022-02094-3
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author Uzel, Mehmet Murat
Gelisken, Faik
Konrad, Eva
Neubauer, Jonas
author_facet Uzel, Mehmet Murat
Gelisken, Faik
Konrad, Eva
Neubauer, Jonas
author_sort Uzel, Mehmet Murat
collection PubMed
description PURPOSE: To analyse the clinical and morphological characteristics of eyes with idiopathic epiretinal membrane (iERM) and foveal herniation (FH). METHODS: Clinical findings and OCT features of patients with iERM and FH were retrospectively analysed. Primary outcome were changes of the best-corrected-visual-acuity (BCVA) and OCT features from baseline to the last visit. FH patients were divided into two groups based on herniated layers: ganglion cell complex (GCC)-group and sub-GCC-group. Surgical outcome was also assessed. RESULTS: In this study, 3882 patients with iERM were screened, of whom 51 (1.3%) were identified with FH. The GCC-group (n = 16) had a better baseline BCVA and thinner central foveal thickness (CFT) in comparison to the sub-GCC-group (n = 35) but without statistical significance (p = 0.330, p = 0.417, respectively). The postoperative BCVA-improvement was similar between the two groups (p = 0.280). Fibrillary surface changes were detected in 42/51 (82.3%) patients, significantly more often in the sub-GCC group (p = 0.020). The baseline BCVA was a predictive factor for the postoperative vision change. CONCLUSION: FH presents with a unique macular morphology in eyes with iERM. Affected eyes experience varying visual disturbances based on the involvement of the inner retinal layers in the foveal herniation. Macular surgery is successful in restoring vision, even though foveal morphology does not fully recover.
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spelling pubmed-101701272023-05-11 Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation Uzel, Mehmet Murat Gelisken, Faik Konrad, Eva Neubauer, Jonas Eye (Lond) Article PURPOSE: To analyse the clinical and morphological characteristics of eyes with idiopathic epiretinal membrane (iERM) and foveal herniation (FH). METHODS: Clinical findings and OCT features of patients with iERM and FH were retrospectively analysed. Primary outcome were changes of the best-corrected-visual-acuity (BCVA) and OCT features from baseline to the last visit. FH patients were divided into two groups based on herniated layers: ganglion cell complex (GCC)-group and sub-GCC-group. Surgical outcome was also assessed. RESULTS: In this study, 3882 patients with iERM were screened, of whom 51 (1.3%) were identified with FH. The GCC-group (n = 16) had a better baseline BCVA and thinner central foveal thickness (CFT) in comparison to the sub-GCC-group (n = 35) but without statistical significance (p = 0.330, p = 0.417, respectively). The postoperative BCVA-improvement was similar between the two groups (p = 0.280). Fibrillary surface changes were detected in 42/51 (82.3%) patients, significantly more often in the sub-GCC group (p = 0.020). The baseline BCVA was a predictive factor for the postoperative vision change. CONCLUSION: FH presents with a unique macular morphology in eyes with iERM. Affected eyes experience varying visual disturbances based on the involvement of the inner retinal layers in the foveal herniation. Macular surgery is successful in restoring vision, even though foveal morphology does not fully recover. Nature Publishing Group UK 2022-06-13 2023-05 /pmc/articles/PMC10170127/ /pubmed/35697750 http://dx.doi.org/10.1038/s41433-022-02094-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Uzel, Mehmet Murat
Gelisken, Faik
Konrad, Eva
Neubauer, Jonas
Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
title Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
title_full Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
title_fullStr Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
title_full_unstemmed Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
title_short Clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
title_sort clinical and morphological characteristics of patients with idiopathic epiretinal membrane with foveal herniation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170127/
https://www.ncbi.nlm.nih.gov/pubmed/35697750
http://dx.doi.org/10.1038/s41433-022-02094-3
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