Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling

The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently confined within various plasma membrane nanodomains, yet how t...

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Detalles Bibliográficos
Autores principales: Sugiyama, Michael G., Brown, Aidan I., Vega-Lugo, Jesus, Borges, Jazlyn P., Scott, Andrew M., Jaqaman, Khuloud, Fairn, Gregory D., Antonescu, Costin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170156/
https://www.ncbi.nlm.nih.gov/pubmed/37160944
http://dx.doi.org/10.1038/s41467-023-38390-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170156/
https://www.ncbi.nlm.nih.gov/pubmed/37160944
http://dx.doi.org/10.1038/s41467-023-38390-z

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