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Chemical Genetics Screen of EVP4593 Sensitivity in Budding Yeast Identifies Effects on Mitochondrial Structure and Function

Mitochondria are essential eukaryotic organelles. Mitochondrial dysfunction can lead to mitochondrial myopathies and may contribute to neurodegenerative diseases, cancer, and diabetes. EVP4593, a 6-aminoquinazoline derivative with therapeutic potential, has been shown to inhibit NADH–ubiquinone oxid...

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Detalles Bibliográficos
Autores principales:	Hiestand, Lexie, Shen, Stella, Sloan, Willough, Nasiri, Hamid, Lashley, Dana, Kerscher, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2023
Materias:	New Finding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170316/ https://www.ncbi.nlm.nih.gov/pubmed/37179969 http://dx.doi.org/10.17912/micropub.biology.000806

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