Cargando…

Cyp4a12-mediated retinol metabolism in stellate cells is the antihepatic fibrosis mechanism of the Chinese medicine Fuzheng Huayu recipe

BACKGROUND: Hepatic stellate cells (HSCs), which contain multiple retinol-containing lipid droplets, are important profibrotic cells in liver fibrosis. Under Cyp4a12a/b oxidation, HSC activation was accompanied by the downregulation of genes involved in retinol metabolism, inducing RAE-1 production....

Descripción completa

Detalles Bibliográficos
Autores principales:	Ping, Da-bing, Sun, Xin, Peng, Yuan, Liu, Cheng-hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170698/ https://www.ncbi.nlm.nih.gov/pubmed/37161575 http://dx.doi.org/10.1186/s13020-023-00754-4

Ejemplares similares

Fuzheng Huayu recipe prevents nutritional fibrosing steatohepatitis in mice
por: Jia, Yan-Hong, et al.
Publicado: (2012)

Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats
por: Yang, Tao, et al.
Publicado: (2019)

Fuzheng Huayu Capsule Attenuates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells
por: Wu, Mei, et al.
Publicado: (2020)

Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis
por: Tao, Yan-yan, et al.
Publicado: (2014)

Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice
por: Jiang, Chunyan, et al.
Publicado: (2020)

Proteomic Analysis of the Effect of Fuzheng Huayu Recipe on Fibrotic Liver in Rats
por: Xie, Hongdong, et al.
Publicado: (2013)

Fuzheng Huayu Recipe Ameliorates Liver Fibrosis by Restoring Balance between Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Hepatic Stellate Cells
por: Pan, Qin, et al.
Publicado: (2015)

Antiliver Fibrosis Formula of Fuzheng Huayu Alleviates Inflammatory Response
por: Chang, Qing-Qi, et al.
Publicado: (2022)

Curative Effects of Fuzheng Huayu on Liver Fibrosis and Cirrhosis: A Meta-Analysis
por: Dong, Shu, et al.
Publicado: (2015)

Effect of Fuzheng Huayu formula and its actions against liver fibrosis
por: Liu, Chenghai, et al.
Publicado: (2009)

Modulation of IKKβ/NF-κB and TGF-β1/Smad via Fuzheng Huayu recipe involves in prevention of nutritional steatohepatitis and fibrosis in mice
por: Wang, Rong-Qi, et al.
Publicado: (2015)

Effect of Fuzheng Huayu capsule combined with Pegasys on genotype 1 hepatitis C fibrosis and cell apoptosis
por: ZHANG, BO, et al.
Publicado: (2014)

Fuzheng Huayu Recipe and its active compounds inhibited HBeAg production by promoting TOMM34 gene expression in HBV-infected hepatocytes
por: Xing, Lu, et al.
Publicado: (2022)

Simultaneous determination of eight analytes of Fuzheng Huayu recipe in beagle dog plasma by UHPLC–Q/exactive Orbitrap HRMS and its application to toxicokinetics
por: Wang, Yu‐Lin, et al.
Publicado: (2022)

Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet
por: Dai, Yun-Kai, et al.
Publicado: (2023)

Fuzheng Huayu Recipe Prevented and Treated CCl4-Induced Mice Liver Fibrosis through Regulating Polarization and Chemotaxis of Intrahepatic Macrophages via CCL2 and CX3CL1
por: Zhang, Man, et al.
Publicado: (2020)

Antihepatic Fibrosis Drugs in Clinical Trials
por: Guo, Yue-Cheng, et al.
Publicado: (2020)

Pharmacological mechanisms of Fuzheng Huayu formula for Aristolochic acid I–induced kidney fibrosis through network pharmacology
por: Wang, Fan, et al.
Publicado: (2022)

The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability – A Network Pharmacology and Transcriptomics Approach
por: Xing, Xinrui, et al.
Publicado: (2018)

Curative Effects of ZHENG-Based Fuzheng-Huayu Tablet on Hepatitis B Caused Cirrhosis Related to CYP1A2 Genetic Polymorphism
por: Li, Qing-Ya, et al.
Publicado: (2013)

Histological Outcome of Fuzheng Huayu plus Entecavir Combination Therapy in Chronic Hepatitis B Patients with Significant Liver Fibrosis
por: Gui, Hong-Lian, et al.
Publicado: (2020)

The components data of fuzheng huayu extracts, cordyceps sinensis mycelia polysaccharide, gypenosides and amygdalin
por: Liu, Wei, et al.
Publicado: (2019)

In Vitro Antibacterial Experiment of Fuzheng Jiedu Huayu Decoction Against Multidrug-Resistant Pseudomonas aeruginosa
por: Xu, Hongri, et al.
Publicado: (2020)

Syndrome of liver depression and spleen deficiency is a primary TCM syndrome of response to entecavir + FuZheng HuaYu in patients with HBV-related liver fibrosis
por: Dai, Yun-kai, et al.
Publicado: (2023)

Efficacy and Safety of a Botanical Formula Fuzheng Huayu for Hepatic Fibrosis in Patients with CHC: Results of a Phase 2 Clinical Trial
por: Hassanein, Tarek, et al.
Publicado: (2022)

Adjuvant Fuzheng Huayu Capsule Reduces the Incidence of Hepatocellular Carcinoma in Patients with Hepatitis B-Caused Cirrhosis
por: Shi, Ke, et al.
Publicado: (2020)

Therapeutic Efficacy of Fuzheng-Huayu Tablet Based Traditional Chinese Medicine Syndrome Differentiation on Hepatitis-B-Caused Cirrhosis: A Multicenter Double-Blind Randomized Controlled Trail
por: Song, Ya-Nan, et al.
Publicado: (2013)

Dynamical Regulation Analysis Identifies Molecular Mechanisms of Fuzheng-Huayu Formula against Hepatitis B-Caused Liver Cirrhosis
por: Chen, Qi-Long, et al.
Publicado: (2015)

A Randomized Controlled Study of Fuzheng Huayu Capsule for Prevention of Esophageal Variceal Bleeding in Patients with Liver Cirrhosis
por: Gu, Jie, et al.
Publicado: (2013)

Active Compounds Derived from Fuzheng Huayu Formula Protect Hepatic Parenchymal Cells from Apoptosis Based on Network Pharmacology and Transcriptomic Analysis
por: Wu, Rong, et al.
Publicado: (2019)

Safety and therapeutic effects of anti-fibrotic Traditional Chinese Medicine Fuzheng Huayu on persistent advanced stage fibrosis following 2 years entecavir treatment: Study protocol for a single arm clinical objective performance criteria trial
por: Chen, Yangyi, et al.
Publicado: (2020)

Investigating the cardioprotective effects of Fuzheng Yangxin recipe based on network pharmacology and experimental evaluation
por: Wang, Anzhu, et al.
Publicado: (2022)

Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats
por: Zhang, Yuxuan, et al.
Publicado: (2020)

The Effect of Qingre Huayu Recipe on Wound Healing after Anal Fistulotomy in Sprague-Dawley Rats
por: Gao, Jiazhi, et al.
Publicado: (2022)

Seroconversión de la vacuna recombinante antihepatitis B. /
por: Cetina Ruz, Mirna Patricia
Publicado: (1996)

Antihepatitis C virus therapy in liver transplanted patients
por: Picciotto, Antonino
Publicado: (2006)

Retracted: The Effect of Qingre Huayu Recipe on Wound Healing after Anal Fistulotomy in Sprague-Dawley Rats
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Retinol from hepatic stellate cells via STRA6 induces lipogenesis on hepatocytes during fibrosis
por: Hwang, Injoo, et al.
Publicado: (2021)

The Medicinal Chemistry of Antihepatitis Agents I: Anti-HAV, Anti-HDV, and Anti-HEV Agents
por: Gupta, Satya P.
Publicado: (2018)

Transcriptional Profiling and miRNA-Target Network Analysis Identify Potential Biomarkers for Efficacy Evaluation of Fuzheng-Huayu Formula-Treated Hepatitis B Caused Liver Cirrhosis
por: Chen, Qilong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_upnh05pvqc8odsf6q7qlr23vje