Cargando…

Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy

BACKGROUND: Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has attracted extensive attention due to the benefits in high maximum permissible exposure and penetration depth. Current photothermal agents generally show a broadband absorption accompanied by a gradual attenuation...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Guoyong, Wang, Shuxian, Wang, Shumin, Wu, Rongrong, Li, Hui, Zha, Menglei, Song, Jibin, Yin, Yuxin, Li, Kai, Mu, Jing, Shi, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170720/
https://www.ncbi.nlm.nih.gov/pubmed/37161467
http://dx.doi.org/10.1186/s12951-023-01887-2
_version_ 1785039281056645120
author Liu, Guoyong
Wang, Shuxian
Wang, Shumin
Wu, Rongrong
Li, Hui
Zha, Menglei
Song, Jibin
Yin, Yuxin
Li, Kai
Mu, Jing
Shi, Yu
author_facet Liu, Guoyong
Wang, Shuxian
Wang, Shumin
Wu, Rongrong
Li, Hui
Zha, Menglei
Song, Jibin
Yin, Yuxin
Li, Kai
Mu, Jing
Shi, Yu
author_sort Liu, Guoyong
collection PubMed
description BACKGROUND: Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has attracted extensive attention due to the benefits in high maximum permissible exposure and penetration depth. Current photothermal agents generally show a broadband absorption accompanied by a gradual attenuation of absorption in the NIR-II window, leading to poor effect of PTT. It remains a great challenge to gain photothermal agents with strong and characteristic absorption in NIR-II regions. To overcome this problem, based on carbon dots (CDs)-mediated growth strategy, we proposed a simple and feasible approach to prepare plasmonic gold nanodendrites (AuNDs) with NIR-II absorption to enhance the therapeutic effect of PTT. RESULTS: By rationally regulating the size and branch length of AuNDs, the AuNDs exhibited a broadband absorption from 300 to 1350 nm, with two characteristic absorption peaks located at 1077 and 1265 nm. The AuNDs demonstrated desired optical photothermal conversion efficiency (38.0%), which was further applied in NIR-II photoacoustic imaging (PAI) and PTT in human colon cancer cells (HCT 116)-tumor-bearing mice model. The tumor cells could be effectively eliminated in vivo under 1064 nm laser irradiation by the guidance of PAI. CONCLUSIONS: We reported a simple but powerful synthetic method to obtain the unique AuNDs with strong and characteristic absorption peaks in the NIR-II window. This study provides a promising solution to tuning the growth of nanoparticles for bioimaging and phototherapy in the NIR-II window. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01887-2.
format Online
Article
Text
id pubmed-10170720
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-101707202023-05-11 Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy Liu, Guoyong Wang, Shuxian Wang, Shumin Wu, Rongrong Li, Hui Zha, Menglei Song, Jibin Yin, Yuxin Li, Kai Mu, Jing Shi, Yu J Nanobiotechnology Research BACKGROUND: Photothermal therapy (PTT) in the second near-infrared (NIR-II) window has attracted extensive attention due to the benefits in high maximum permissible exposure and penetration depth. Current photothermal agents generally show a broadband absorption accompanied by a gradual attenuation of absorption in the NIR-II window, leading to poor effect of PTT. It remains a great challenge to gain photothermal agents with strong and characteristic absorption in NIR-II regions. To overcome this problem, based on carbon dots (CDs)-mediated growth strategy, we proposed a simple and feasible approach to prepare plasmonic gold nanodendrites (AuNDs) with NIR-II absorption to enhance the therapeutic effect of PTT. RESULTS: By rationally regulating the size and branch length of AuNDs, the AuNDs exhibited a broadband absorption from 300 to 1350 nm, with two characteristic absorption peaks located at 1077 and 1265 nm. The AuNDs demonstrated desired optical photothermal conversion efficiency (38.0%), which was further applied in NIR-II photoacoustic imaging (PAI) and PTT in human colon cancer cells (HCT 116)-tumor-bearing mice model. The tumor cells could be effectively eliminated in vivo under 1064 nm laser irradiation by the guidance of PAI. CONCLUSIONS: We reported a simple but powerful synthetic method to obtain the unique AuNDs with strong and characteristic absorption peaks in the NIR-II window. This study provides a promising solution to tuning the growth of nanoparticles for bioimaging and phototherapy in the NIR-II window. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01887-2. BioMed Central 2023-05-09 /pmc/articles/PMC10170720/ /pubmed/37161467 http://dx.doi.org/10.1186/s12951-023-01887-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Guoyong
Wang, Shuxian
Wang, Shumin
Wu, Rongrong
Li, Hui
Zha, Menglei
Song, Jibin
Yin, Yuxin
Li, Kai
Mu, Jing
Shi, Yu
Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy
title Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy
title_full Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy
title_fullStr Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy
title_full_unstemmed Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy
title_short Carbon dots-mediated synthesis of gold nanodendrites with extended absorption into NIR-II window for in vivo photothermal therapy
title_sort carbon dots-mediated synthesis of gold nanodendrites with extended absorption into nir-ii window for in vivo photothermal therapy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170720/
https://www.ncbi.nlm.nih.gov/pubmed/37161467
http://dx.doi.org/10.1186/s12951-023-01887-2
work_keys_str_mv AT liuguoyong carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT wangshuxian carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT wangshumin carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT wurongrong carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT lihui carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT zhamenglei carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT songjibin carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT yinyuxin carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT likai carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT mujing carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy
AT shiyu carbondotsmediatedsynthesisofgoldnanodendriteswithextendedabsorptionintoniriiwindowforinvivophotothermaltherapy