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Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia

OBJECTIVE: To evaluate the result of gamma knife radiosurgery (GKRS) for drug-resistant primary trigeminal neuralgia (TN). METHODS: Patients who were diagnosed with drug-resistant primary TN were treated with GKRS at the Nuclear Medicine and Oncology Center, Bach Mai Hospital from January 2015 to Ju...

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Autores principales: Dinh, Hung Kieu, Minh, Tan Hoang, Van, Thinh Le, Trong, Khoa Mai, Quang, Hung Nguyen, Quang, Truong Doan, Huong, Giang Nguyen Thi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171000/
https://www.ncbi.nlm.nih.gov/pubmed/37179673
http://dx.doi.org/10.4103/aian.aian_987_21
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author Dinh, Hung Kieu
Minh, Tan Hoang
Van, Thinh Le
Trong, Khoa Mai
Quang, Hung Nguyen
Quang, Truong Doan
Huong, Giang Nguyen Thi
author_facet Dinh, Hung Kieu
Minh, Tan Hoang
Van, Thinh Le
Trong, Khoa Mai
Quang, Hung Nguyen
Quang, Truong Doan
Huong, Giang Nguyen Thi
author_sort Dinh, Hung Kieu
collection PubMed
description OBJECTIVE: To evaluate the result of gamma knife radiosurgery (GKRS) for drug-resistant primary trigeminal neuralgia (TN). METHODS: Patients who were diagnosed with drug-resistant primary TN were treated with GKRS at the Nuclear Medicine and Oncology Center, Bach Mai Hospital from January 2015 to June 2020. Using the pain rating scale of the Barrow Neurological Institute (BNI), follow-ups and evaluations were conducted at 1 month, 3 months, 6 months, and 9 month, and 1, 2 years, 3 years, and 5 years after radiosurgery. Comparisons of pain levels was performed before and after radiosurgery according to the BNI scale. RESULTS: From January 2015 to June 2020, 33 patients were treated with GKS. There were 23 female patients and 10 male patients; the average age was 61.9. The average onset time of disease was 4.42 years. Among all patients, 84.8% of patients were relieved from pain and 78.8% were pain-free without medication. The mean time for pain relief was 3 months and was not related to the dose of GKS (<80 Gy and ≥80 Gy). The efficacy of pain relief is not related to blood vessel contact with the trigeminal nerve, the dose of GKS, and the onset of disease. The rate of recurrence after the first pain relief was low (14.3%). CONCLUSIONS: Gamma knife is an effective method for the treatment of primary drug-resistant TN, especially in elderly patients with underlying medical conditions. The analgesic effect does not depend on the presence of nerve-vascular conflict.
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spelling pubmed-101710002023-05-11 Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia Dinh, Hung Kieu Minh, Tan Hoang Van, Thinh Le Trong, Khoa Mai Quang, Hung Nguyen Quang, Truong Doan Huong, Giang Nguyen Thi Ann Indian Acad Neurol Original Article OBJECTIVE: To evaluate the result of gamma knife radiosurgery (GKRS) for drug-resistant primary trigeminal neuralgia (TN). METHODS: Patients who were diagnosed with drug-resistant primary TN were treated with GKRS at the Nuclear Medicine and Oncology Center, Bach Mai Hospital from January 2015 to June 2020. Using the pain rating scale of the Barrow Neurological Institute (BNI), follow-ups and evaluations were conducted at 1 month, 3 months, 6 months, and 9 month, and 1, 2 years, 3 years, and 5 years after radiosurgery. Comparisons of pain levels was performed before and after radiosurgery according to the BNI scale. RESULTS: From January 2015 to June 2020, 33 patients were treated with GKS. There were 23 female patients and 10 male patients; the average age was 61.9. The average onset time of disease was 4.42 years. Among all patients, 84.8% of patients were relieved from pain and 78.8% were pain-free without medication. The mean time for pain relief was 3 months and was not related to the dose of GKS (<80 Gy and ≥80 Gy). The efficacy of pain relief is not related to blood vessel contact with the trigeminal nerve, the dose of GKS, and the onset of disease. The rate of recurrence after the first pain relief was low (14.3%). CONCLUSIONS: Gamma knife is an effective method for the treatment of primary drug-resistant TN, especially in elderly patients with underlying medical conditions. The analgesic effect does not depend on the presence of nerve-vascular conflict. Wolters Kluwer - Medknow 2023 2023-03-17 /pmc/articles/PMC10171000/ /pubmed/37179673 http://dx.doi.org/10.4103/aian.aian_987_21 Text en Copyright: © 2023 Annals of Indian Academy of Neurology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Dinh, Hung Kieu
Minh, Tan Hoang
Van, Thinh Le
Trong, Khoa Mai
Quang, Hung Nguyen
Quang, Truong Doan
Huong, Giang Nguyen Thi
Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia
title Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia
title_full Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia
title_fullStr Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia
title_full_unstemmed Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia
title_short Outcomes of Gamma Knife Radiosurgery for Drug-Resistant Primary Trigeminal Neuralgia
title_sort outcomes of gamma knife radiosurgery for drug-resistant primary trigeminal neuralgia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171000/
https://www.ncbi.nlm.nih.gov/pubmed/37179673
http://dx.doi.org/10.4103/aian.aian_987_21
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