H3G34-mutant diffuse hemispheric glioma with osseous metastases: a case report and literature review

AIM: H3G34 diffuse hemispheric glioma is a CNS tumor that is difficult to diagnose and treat and accompanied with poor prognosis. It is becoming clear that extra CNS metastasis may present in a subset of patients with H3G34 gliomas, further complicating diagnosis and treatment. MATERIALS & METHO...

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Detalles Bibliográficos
Autores principales: Yu, Nina, Lee, Han Sung, Raslan, Osama A, Jin, Lee-Way, Aboud, Orwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171036/
https://www.ncbi.nlm.nih.gov/pubmed/36919796
http://dx.doi.org/10.2217/cns-2022-0020
Descripción
Sumario:AIM: H3G34 diffuse hemispheric glioma is a CNS tumor that is difficult to diagnose and treat and accompanied with poor prognosis. It is becoming clear that extra CNS metastasis may present in a subset of patients with H3G34 gliomas, further complicating diagnosis and treatment. MATERIALS & METHODS: We present a case of a 19-year-old female with a H3G34 mutant diffuse hemispheric glioma with osseous metastases. We then provide a literature review of the most recent understanding of H3G34 mutant malignancies. CONCLUSION: Given the stress that patients with H3G34 can experience and the poor prognosis, it is imperative to expand our knowledge and ascertain accurate diagnostic methodologies and targeted therapeutic approaches.

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