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Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses
Influenza and Respiratory Syncytial virus (RSV) infections together contribute significantly to the burden of acute lower respiratory tract infections. Despite the disease burden, no approved RSV vaccine is available. While approved vaccines are available for influenza, seasonal vaccination is requi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171128/ https://www.ncbi.nlm.nih.gov/pubmed/36927227 http://dx.doi.org/10.1080/22221751.2023.2192821 |
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author | Raman, Sathya N. Thulasi Zetner, Adrian Hashem, Anwar M. Patel, Devina Wu, Jianguo Gravel, Caroline Gao, Jun Zhang, Wanyue Pfeifle, Annabelle Tamming, Levi Parikh, Karan Cao, Jingxin Tam, Roger Safronetz, David Chen, Wangxue Johnston, Michael J.W. Wang, Lisheng Sauve, Simon Rosu-Myles, Michael Domselaar, Gary Van Li, Xuguang |
author_facet | Raman, Sathya N. Thulasi Zetner, Adrian Hashem, Anwar M. Patel, Devina Wu, Jianguo Gravel, Caroline Gao, Jun Zhang, Wanyue Pfeifle, Annabelle Tamming, Levi Parikh, Karan Cao, Jingxin Tam, Roger Safronetz, David Chen, Wangxue Johnston, Michael J.W. Wang, Lisheng Sauve, Simon Rosu-Myles, Michael Domselaar, Gary Van Li, Xuguang |
author_sort | Raman, Sathya N. Thulasi |
collection | PubMed |
description | Influenza and Respiratory Syncytial virus (RSV) infections together contribute significantly to the burden of acute lower respiratory tract infections. Despite the disease burden, no approved RSV vaccine is available. While approved vaccines are available for influenza, seasonal vaccination is required to maintain protection. In addition to both being respiratory viruses, they follow a common seasonality, which warrants the necessity for a concerted vaccination approach. Here, we designed bivalent vaccines by utilizing highly conserved sequences, targeting both influenza A and RSV, as either a chimeric antigen or individual antigens separated by a ribosome skipping sequence. These vaccines were found to be effective in protecting the animals from challenge by either virus, with mechanisms of protection being substantially interrogated in this communication. |
format | Online Article Text |
id | pubmed-10171128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-101711282023-05-11 Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses Raman, Sathya N. Thulasi Zetner, Adrian Hashem, Anwar M. Patel, Devina Wu, Jianguo Gravel, Caroline Gao, Jun Zhang, Wanyue Pfeifle, Annabelle Tamming, Levi Parikh, Karan Cao, Jingxin Tam, Roger Safronetz, David Chen, Wangxue Johnston, Michael J.W. Wang, Lisheng Sauve, Simon Rosu-Myles, Michael Domselaar, Gary Van Li, Xuguang Emerg Microbes Infect Non-Neutralizing Protective Antibodies Influenza and Respiratory Syncytial virus (RSV) infections together contribute significantly to the burden of acute lower respiratory tract infections. Despite the disease burden, no approved RSV vaccine is available. While approved vaccines are available for influenza, seasonal vaccination is required to maintain protection. In addition to both being respiratory viruses, they follow a common seasonality, which warrants the necessity for a concerted vaccination approach. Here, we designed bivalent vaccines by utilizing highly conserved sequences, targeting both influenza A and RSV, as either a chimeric antigen or individual antigens separated by a ribosome skipping sequence. These vaccines were found to be effective in protecting the animals from challenge by either virus, with mechanisms of protection being substantially interrogated in this communication. Taylor & Francis 2023-05-09 /pmc/articles/PMC10171128/ /pubmed/36927227 http://dx.doi.org/10.1080/22221751.2023.2192821 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Non-Neutralizing Protective Antibodies Raman, Sathya N. Thulasi Zetner, Adrian Hashem, Anwar M. Patel, Devina Wu, Jianguo Gravel, Caroline Gao, Jun Zhang, Wanyue Pfeifle, Annabelle Tamming, Levi Parikh, Karan Cao, Jingxin Tam, Roger Safronetz, David Chen, Wangxue Johnston, Michael J.W. Wang, Lisheng Sauve, Simon Rosu-Myles, Michael Domselaar, Gary Van Li, Xuguang Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses |
title | Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses |
title_full | Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses |
title_fullStr | Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses |
title_full_unstemmed | Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses |
title_short | Bivalent vaccines effectively protect mice against influenza A and respiratory syncytial viruses |
title_sort | bivalent vaccines effectively protect mice against influenza a and respiratory syncytial viruses |
topic | Non-Neutralizing Protective Antibodies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171128/ https://www.ncbi.nlm.nih.gov/pubmed/36927227 http://dx.doi.org/10.1080/22221751.2023.2192821 |
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