NAD(+) metabolism-based immunoregulation and therapeutic potential

Nicotinamide adenine dinucleotide (NAD(+)) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD(+)-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD(+) metabolism can regulate functionality attributes of...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Jiankai, Chen, Wangwang, Hou, Pengbo, Liu, Zhanhong, Zuo, Muqiu, Liu, Shisong, Feng, Chao, Han, Yuyi, Li, Peishan, Shi, Yufang, Shao, Changshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171153/
https://www.ncbi.nlm.nih.gov/pubmed/37165408
http://dx.doi.org/10.1186/s13578-023-01031-5
_version_ 1785039368064335872
author Fang, Jiankai
Chen, Wangwang
Hou, Pengbo
Liu, Zhanhong
Zuo, Muqiu
Liu, Shisong
Feng, Chao
Han, Yuyi
Li, Peishan
Shi, Yufang
Shao, Changshun
author_facet Fang, Jiankai
Chen, Wangwang
Hou, Pengbo
Liu, Zhanhong
Zuo, Muqiu
Liu, Shisong
Feng, Chao
Han, Yuyi
Li, Peishan
Shi, Yufang
Shao, Changshun
author_sort Fang, Jiankai
collection PubMed
description Nicotinamide adenine dinucleotide (NAD(+)) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD(+)-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD(+) metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD(+) bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD(+) biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD(+) research in the development of therapeutics for inflammatory diseases, such as COVID-19.
format Online
Article
Text
id pubmed-10171153
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-101711532023-05-11 NAD(+) metabolism-based immunoregulation and therapeutic potential Fang, Jiankai Chen, Wangwang Hou, Pengbo Liu, Zhanhong Zuo, Muqiu Liu, Shisong Feng, Chao Han, Yuyi Li, Peishan Shi, Yufang Shao, Changshun Cell Biosci Review Nicotinamide adenine dinucleotide (NAD(+)) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD(+)-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD(+) metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD(+) bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD(+) biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD(+) research in the development of therapeutics for inflammatory diseases, such as COVID-19. BioMed Central 2023-05-10 /pmc/articles/PMC10171153/ /pubmed/37165408 http://dx.doi.org/10.1186/s13578-023-01031-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Fang, Jiankai
Chen, Wangwang
Hou, Pengbo
Liu, Zhanhong
Zuo, Muqiu
Liu, Shisong
Feng, Chao
Han, Yuyi
Li, Peishan
Shi, Yufang
Shao, Changshun
NAD(+) metabolism-based immunoregulation and therapeutic potential
title NAD(+) metabolism-based immunoregulation and therapeutic potential
title_full NAD(+) metabolism-based immunoregulation and therapeutic potential
title_fullStr NAD(+) metabolism-based immunoregulation and therapeutic potential
title_full_unstemmed NAD(+) metabolism-based immunoregulation and therapeutic potential
title_short NAD(+) metabolism-based immunoregulation and therapeutic potential
title_sort nad(+) metabolism-based immunoregulation and therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171153/
https://www.ncbi.nlm.nih.gov/pubmed/37165408
http://dx.doi.org/10.1186/s13578-023-01031-5
work_keys_str_mv AT fangjiankai nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT chenwangwang nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT houpengbo nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT liuzhanhong nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT zuomuqiu nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT liushisong nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT fengchao nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT hanyuyi nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT lipeishan nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT shiyufang nadmetabolismbasedimmunoregulationandtherapeuticpotential
AT shaochangshun nadmetabolismbasedimmunoregulationandtherapeuticpotential

Ejemplares similares