Knowledge Mapping of Opioids and Immunomodulation: A Bibliometric Analysis (2000–2022)

BACKGROUND: Increasing evidence indicates that opioids markedly affect the immune system. However, there are few studies on opioids and immunomodulation using bibliometric analysis. PURPOSE: We aimed to provide a comprehensive overview of the research status and trends of the influence of opioids on immunomodulation using a bibliometric approach. METHODS: Articles related to opioids and immunomodulation published from 2000 to 2022 were obtained from the Science Citation Index Expanded of the Web of Science Core Collection by searching keywords related to opioids and immunomodulation. Bibliometric analyses and visualizations were conducted using the CiteSpace and VOSviewer software programs. RESULTS: From 2000 to 2022, a total of 3242 research articles on opioids and immunomodulation were published in 1126 academic journals by 16,555 authors in 3368 institutions from 102 countries/regions. A majority of publications were from the US and China, and the University of Minnesota System and Chinese Academy of Sciences were the most active institutions. Tsong-long Hwang had published the most papers, while Sabita Roy had the most cocitations. The Journal of Ethnopharmacology published the most papers on opioids and immunomodulation, the Journal of Immunology was the top cocited journal, and the major area of these publications were molecular, biological, and genetic. The top three keywords were “expression”, “activation”, and “inflammation.” CONCLUSION: The number of studies on opioids and immunomodulation has increased sharply all over the world in the last two decades. This is the first bibliometric study to comprehensively summarize the collaboration network in this field. It will help scholars to understand not only the basic knowledge structure but also potential collaborations, research trend topics, and hot directions.