A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer (IBC). Due to a lack of biomarkers able to distinguish high- from low-risk cases, DCIS is treated similar to early IBC even though the minority of untreated cases eventually become invasive. Here, we characterized...

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Autores principales: Hutten, Stefan J., de Bruijn, Roebi, Lutz, Catrin, Badoux, Madelon, Eijkman, Timo, Chao, Xue, Ciwinska, Marta, Sheinman, Michael, Messal, Hendrik, Herencia-Ropero, Andrea, Kristel, Petra, Mulder, Lennart, van der Waal, Rens, Sanders, Joyce, Almekinders, Mathilde M., Llop-Guevara, Alba, Davies, Helen R., van Haren, Matthijs J., Martin, Nathaniel I., Behbod, Fariba, Nik-Zainal, Serena, Serra, Violeta, van Rheenen, Jacco, Lips, Esther H., Wessels, Lodewyk F.A., Wesseling, Jelle, Scheele, Colinda L.G.J., Jonkers, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171335/
https://www.ncbi.nlm.nih.gov/pubmed/37116492
http://dx.doi.org/10.1016/j.ccell.2023.04.002
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author Hutten, Stefan J.
de Bruijn, Roebi
Lutz, Catrin
Badoux, Madelon
Eijkman, Timo
Chao, Xue
Ciwinska, Marta
Sheinman, Michael
Messal, Hendrik
Herencia-Ropero, Andrea
Kristel, Petra
Mulder, Lennart
van der Waal, Rens
Sanders, Joyce
Almekinders, Mathilde M.
Llop-Guevara, Alba
Davies, Helen R.
van Haren, Matthijs J.
Martin, Nathaniel I.
Behbod, Fariba
Nik-Zainal, Serena
Serra, Violeta
van Rheenen, Jacco
Lips, Esther H.
Wessels, Lodewyk F.A.
Wesseling, Jelle
Scheele, Colinda L.G.J.
Jonkers, Jos
author_facet Hutten, Stefan J.
de Bruijn, Roebi
Lutz, Catrin
Badoux, Madelon
Eijkman, Timo
Chao, Xue
Ciwinska, Marta
Sheinman, Michael
Messal, Hendrik
Herencia-Ropero, Andrea
Kristel, Petra
Mulder, Lennart
van der Waal, Rens
Sanders, Joyce
Almekinders, Mathilde M.
Llop-Guevara, Alba
Davies, Helen R.
van Haren, Matthijs J.
Martin, Nathaniel I.
Behbod, Fariba
Nik-Zainal, Serena
Serra, Violeta
van Rheenen, Jacco
Lips, Esther H.
Wessels, Lodewyk F.A.
Wesseling, Jelle
Scheele, Colinda L.G.J.
Jonkers, Jos
author_sort Hutten, Stefan J.
collection PubMed
description Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer (IBC). Due to a lack of biomarkers able to distinguish high- from low-risk cases, DCIS is treated similar to early IBC even though the minority of untreated cases eventually become invasive. Here, we characterized 115 patient-derived mouse-intraductal (MIND) DCIS models reflecting the full spectrum of DCIS observed in patients. Utilizing the possibility to follow the natural progression of DCIS combined with omics and imaging data, we reveal multiple prognostic factors for high-risk DCIS including high grade, HER2 amplification, expansive 3D growth, and high burden of copy number aberrations. In addition, sequential transplantation of xenografts showed minimal phenotypic and genotypic changes over time, indicating that invasive behavior is an intrinsic phenotype of DCIS and supporting a multiclonal evolution model. Moreover, this study provides a collection of 19 distributable DCIS-MIND models spanning all molecular subtypes.
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spelling pubmed-101713352023-05-11 A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression Hutten, Stefan J. de Bruijn, Roebi Lutz, Catrin Badoux, Madelon Eijkman, Timo Chao, Xue Ciwinska, Marta Sheinman, Michael Messal, Hendrik Herencia-Ropero, Andrea Kristel, Petra Mulder, Lennart van der Waal, Rens Sanders, Joyce Almekinders, Mathilde M. Llop-Guevara, Alba Davies, Helen R. van Haren, Matthijs J. Martin, Nathaniel I. Behbod, Fariba Nik-Zainal, Serena Serra, Violeta van Rheenen, Jacco Lips, Esther H. Wessels, Lodewyk F.A. Wesseling, Jelle Scheele, Colinda L.G.J. Jonkers, Jos Cancer Cell Article Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer (IBC). Due to a lack of biomarkers able to distinguish high- from low-risk cases, DCIS is treated similar to early IBC even though the minority of untreated cases eventually become invasive. Here, we characterized 115 patient-derived mouse-intraductal (MIND) DCIS models reflecting the full spectrum of DCIS observed in patients. Utilizing the possibility to follow the natural progression of DCIS combined with omics and imaging data, we reveal multiple prognostic factors for high-risk DCIS including high grade, HER2 amplification, expansive 3D growth, and high burden of copy number aberrations. In addition, sequential transplantation of xenografts showed minimal phenotypic and genotypic changes over time, indicating that invasive behavior is an intrinsic phenotype of DCIS and supporting a multiclonal evolution model. Moreover, this study provides a collection of 19 distributable DCIS-MIND models spanning all molecular subtypes. Cell Press 2023-05-08 /pmc/articles/PMC10171335/ /pubmed/37116492 http://dx.doi.org/10.1016/j.ccell.2023.04.002 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hutten, Stefan J.
de Bruijn, Roebi
Lutz, Catrin
Badoux, Madelon
Eijkman, Timo
Chao, Xue
Ciwinska, Marta
Sheinman, Michael
Messal, Hendrik
Herencia-Ropero, Andrea
Kristel, Petra
Mulder, Lennart
van der Waal, Rens
Sanders, Joyce
Almekinders, Mathilde M.
Llop-Guevara, Alba
Davies, Helen R.
van Haren, Matthijs J.
Martin, Nathaniel I.
Behbod, Fariba
Nik-Zainal, Serena
Serra, Violeta
van Rheenen, Jacco
Lips, Esther H.
Wessels, Lodewyk F.A.
Wesseling, Jelle
Scheele, Colinda L.G.J.
Jonkers, Jos
A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
title A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
title_full A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
title_fullStr A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
title_full_unstemmed A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
title_short A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
title_sort living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171335/
https://www.ncbi.nlm.nih.gov/pubmed/37116492
http://dx.doi.org/10.1016/j.ccell.2023.04.002
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