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Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response

One of the adverse outcomes of acute inflammatory response is progressing to the chronic stage or transforming into an aggressive process, which can develop rapidly and result in the multiple organ dysfunction syndrome. The leading role in this process is played by the Systemic Inflammatory Response...

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Autores principales: Kostenko, Vitalii, Akimov, Oleh, Gutnik, Oleksandr, Kostenko, Heorhii, Kostenko, Viktoriia, Romantseva, Tamara, Morhun, Yevhen, Nazarenko, Svitlana, Taran, Olena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171461/
https://www.ncbi.nlm.nih.gov/pubmed/37180884
http://dx.doi.org/10.1016/j.heliyon.2023.e15551
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author Kostenko, Vitalii
Akimov, Oleh
Gutnik, Oleksandr
Kostenko, Heorhii
Kostenko, Viktoriia
Romantseva, Tamara
Morhun, Yevhen
Nazarenko, Svitlana
Taran, Olena
author_facet Kostenko, Vitalii
Akimov, Oleh
Gutnik, Oleksandr
Kostenko, Heorhii
Kostenko, Viktoriia
Romantseva, Tamara
Morhun, Yevhen
Nazarenko, Svitlana
Taran, Olena
author_sort Kostenko, Vitalii
collection PubMed
description One of the adverse outcomes of acute inflammatory response is progressing to the chronic stage or transforming into an aggressive process, which can develop rapidly and result in the multiple organ dysfunction syndrome. The leading role in this process is played by the Systemic Inflammatory Response that is accompanied by the production of pro- and anti-inflammatory cytokines, acute phase proteins, and reactive oxygen and nitrogen species. The purpose of this review that highlights both the recent reports and the results of the authors' own research is to encourage scientists to develop new approaches to the differentiated therapy of various SIR manifestations (low- and high-grade systemic inflammatory response phenotypes) by modulating redox-sensitive transcription factors with polyphenols and to evaluate the saturation of the pharmaceutical market with appropriate dosage forms tailored for targeted delivery of these compounds. Redox-sensitive transcription factors such as NFκB, STAT3, AP1 and Nrf2 have a leading role in mechanisms of the formation of low- and high-grade systemic inflammatory phenotypes as variants of SIR. These phenotypic variants underlie the pathogenesis of the most dangerous diseases of internal organs, endocrine and nervous systems, surgical pathologies, and post-traumatic disorders. The use of individual chemical compounds of the class of polyphenols, or their combinations can be an effective technology in the therapy of SIR. Administering natural polyphenols in oral dosage forms is very beneficial in the therapy and management of the number of diseases accompanied with low-grade systemic inflammatory phenotype. The therapy of diseases associated with high-grade systemic inflammatory phenotype requires medicinal phenol preparations manufactured for parenteral administration.
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spelling pubmed-101714612023-05-11 Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response Kostenko, Vitalii Akimov, Oleh Gutnik, Oleksandr Kostenko, Heorhii Kostenko, Viktoriia Romantseva, Tamara Morhun, Yevhen Nazarenko, Svitlana Taran, Olena Heliyon Review Article One of the adverse outcomes of acute inflammatory response is progressing to the chronic stage or transforming into an aggressive process, which can develop rapidly and result in the multiple organ dysfunction syndrome. The leading role in this process is played by the Systemic Inflammatory Response that is accompanied by the production of pro- and anti-inflammatory cytokines, acute phase proteins, and reactive oxygen and nitrogen species. The purpose of this review that highlights both the recent reports and the results of the authors' own research is to encourage scientists to develop new approaches to the differentiated therapy of various SIR manifestations (low- and high-grade systemic inflammatory response phenotypes) by modulating redox-sensitive transcription factors with polyphenols and to evaluate the saturation of the pharmaceutical market with appropriate dosage forms tailored for targeted delivery of these compounds. Redox-sensitive transcription factors such as NFκB, STAT3, AP1 and Nrf2 have a leading role in mechanisms of the formation of low- and high-grade systemic inflammatory phenotypes as variants of SIR. These phenotypic variants underlie the pathogenesis of the most dangerous diseases of internal organs, endocrine and nervous systems, surgical pathologies, and post-traumatic disorders. The use of individual chemical compounds of the class of polyphenols, or their combinations can be an effective technology in the therapy of SIR. Administering natural polyphenols in oral dosage forms is very beneficial in the therapy and management of the number of diseases accompanied with low-grade systemic inflammatory phenotype. The therapy of diseases associated with high-grade systemic inflammatory phenotype requires medicinal phenol preparations manufactured for parenteral administration. Elsevier 2023-04-16 /pmc/articles/PMC10171461/ /pubmed/37180884 http://dx.doi.org/10.1016/j.heliyon.2023.e15551 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Kostenko, Vitalii
Akimov, Oleh
Gutnik, Oleksandr
Kostenko, Heorhii
Kostenko, Viktoriia
Romantseva, Tamara
Morhun, Yevhen
Nazarenko, Svitlana
Taran, Olena
Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
title Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
title_full Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
title_fullStr Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
title_full_unstemmed Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
title_short Modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
title_sort modulation of redox-sensitive transcription factors with polyphenols as pathogenetically grounded approach in therapy of systemic inflammatory response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171461/
https://www.ncbi.nlm.nih.gov/pubmed/37180884
http://dx.doi.org/10.1016/j.heliyon.2023.e15551
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