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Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves

The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly un...

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Autores principales: Panja, Amrita, Roy, Jayita, Mazumder, Anup, Choudhury, Sujata Maiti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171727/
https://www.ncbi.nlm.nih.gov/pubmed/37363365
http://dx.doi.org/10.1007/s13337-023-00823-0
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author Panja, Amrita
Roy, Jayita
Mazumder, Anup
Choudhury, Sujata Maiti
author_facet Panja, Amrita
Roy, Jayita
Mazumder, Anup
Choudhury, Sujata Maiti
author_sort Panja, Amrita
collection PubMed
description The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13337-023-00823-0.
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spelling pubmed-101717272023-05-11 Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves Panja, Amrita Roy, Jayita Mazumder, Anup Choudhury, Sujata Maiti Virusdisease Original Article The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13337-023-00823-0. Springer India 2023-05-10 2023-06 /pmc/articles/PMC10171727/ /pubmed/37363365 http://dx.doi.org/10.1007/s13337-023-00823-0 Text en © The Author(s), under exclusive licence to Indian Virological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
spellingShingle Original Article
Panja, Amrita
Roy, Jayita
Mazumder, Anup
Choudhury, Sujata Maiti
Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
title Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
title_full Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
title_fullStr Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
title_full_unstemmed Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
title_short Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
title_sort divergent mutations of delta and omicron variants: key players behind differential viral attributes across the covid-19 waves
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171727/
https://www.ncbi.nlm.nih.gov/pubmed/37363365
http://dx.doi.org/10.1007/s13337-023-00823-0
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