Cargando…
Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves
The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly un...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171727/ https://www.ncbi.nlm.nih.gov/pubmed/37363365 http://dx.doi.org/10.1007/s13337-023-00823-0 |
_version_ | 1785039484032647168 |
---|---|
author | Panja, Amrita Roy, Jayita Mazumder, Anup Choudhury, Sujata Maiti |
author_facet | Panja, Amrita Roy, Jayita Mazumder, Anup Choudhury, Sujata Maiti |
author_sort | Panja, Amrita |
collection | PubMed |
description | The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13337-023-00823-0. |
format | Online Article Text |
id | pubmed-10171727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-101717272023-05-11 Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves Panja, Amrita Roy, Jayita Mazumder, Anup Choudhury, Sujata Maiti Virusdisease Original Article The third SARS-CoV-2 pandemic wave causing Omicron variant has comparatively higher replication rate and transmissibility than the second wave-causing Delta variant. The exact mechanism behind the differential properties of Delta and Omicron in respect to infectivity and virulence is not properly understood yet. This study reports the analysis of different mutations within the receptor binding domain (RBD) of spike glycoprotein and non-structural protein (nsp) of Delta and Omicron strains. We have used computational studies to evaluate the properties of Delta and Omicron variants in this work. Q498R, Q493R and S375F mutations of RBD showed better docking scores for Omicron compared to Delta variant of SARS-CoV-2, whereas nsp3_L1266I with PARP15 (7OUX), nsp3_L1266I with PARP15 (7OUX), and nsp6_G107 with ISG15 (1Z2M) showed significantly higher docking score. The findings of the present study might be helpful to reveal the probable cause of relatively milder form of COVID-19 disease manifested by Omicron in comparison to Delta variant of SARS-CoV-2 virus. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13337-023-00823-0. Springer India 2023-05-10 2023-06 /pmc/articles/PMC10171727/ /pubmed/37363365 http://dx.doi.org/10.1007/s13337-023-00823-0 Text en © The Author(s), under exclusive licence to Indian Virological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
spellingShingle | Original Article Panja, Amrita Roy, Jayita Mazumder, Anup Choudhury, Sujata Maiti Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves |
title | Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves |
title_full | Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves |
title_fullStr | Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves |
title_full_unstemmed | Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves |
title_short | Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves |
title_sort | divergent mutations of delta and omicron variants: key players behind differential viral attributes across the covid-19 waves |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171727/ https://www.ncbi.nlm.nih.gov/pubmed/37363365 http://dx.doi.org/10.1007/s13337-023-00823-0 |
work_keys_str_mv | AT panjaamrita divergentmutationsofdeltaandomicronvariantskeyplayersbehinddifferentialviralattributesacrossthecovid19waves AT royjayita divergentmutationsofdeltaandomicronvariantskeyplayersbehinddifferentialviralattributesacrossthecovid19waves AT mazumderanup divergentmutationsofdeltaandomicronvariantskeyplayersbehinddifferentialviralattributesacrossthecovid19waves AT choudhurysujatamaiti divergentmutationsofdeltaandomicronvariantskeyplayersbehinddifferentialviralattributesacrossthecovid19waves |