Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells

Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women. LAM cells carry TSC1/TSC2 mutations, causing mTORC1 hyperactivation and uncontrolled cell growth. mTORC1 inhibitors stabilize lung function; however, sustained efficacy requires long-term administrat...

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Detalles Bibliográficos
Autores principales: Olatoke, Tasnim, Wagner, Andrew, Astrinidis, Aristotelis, Zhang, Erik Y., Guo, Minzhe, Zhang, Alan G., Mattam, Ushodaya, Kopras, Elizabeth J., Gupta, Nishant, Smith, Eric P., Karbowniczek, Magdalena, Markiewski, Maciej M., Wikenheiser-Brokamp, Kathryn A., Whitsett, Jeffrey A., McCormack, Francis X., Xu, Yan, Yu, Jane J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171823/
https://www.ncbi.nlm.nih.gov/pubmed/37163604
http://dx.doi.org/10.1126/sciadv.adf8549

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