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Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair

Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 protects genome stability, yet its role in tumorigenesis is unknown. Here, we show that attenuated CTC1/STN1 expression is...

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Detalles Bibliográficos
Autores principales:	Nguyen, Dinh Duc, Kim, Eugene, Le, Nhat Thong, Ding, Xianzhong, Jaiswal, Rishi Kumar, Kostlan, Raymond Joseph, Nguyen, Thi Ngoc Thanh, Shiva, Olga, Le, Minh Thong, Chai, Weihang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171824/ https://www.ncbi.nlm.nih.gov/pubmed/37163605 http://dx.doi.org/10.1126/sciadv.add8023

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