PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

Conditional deletion of the PTH1R in mesenchymal progenitors reduces osteoblast differentiation, enhances marrow adipogenesis, and increases zinc finger protein 467 (Zfp467) expression. In contrast, genetic loss of Zfp467 increased Pth1r expression and shifts mesenchymal progenitor cell fate toward...

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Detalles Bibliográficos
Autores principales: Liu, Hanghang, Wada, Akane, Le, Isabella, Le, Phuong T, Lee, Andrew WF, Zhou, Jun, Gori, Francesca, Baron, Roland, Rosen, Clifford J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171860/
https://www.ncbi.nlm.nih.gov/pubmed/37159501
http://dx.doi.org/10.7554/eLife.83345

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