cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

The cerebellum is involved in learning of fine motor skills, yet whether presynaptic plasticity contributes to such learning remains elusive. Here, we report that the EPAC-PKCε module has a critical role in a presynaptic form of long-term potentiation in the cerebellum and motor behavior in mice. Pr...

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Detalles Bibliográficos
Autores principales: Wang, Xin-Tai, Zhou, Lin, Dong, Bin-Bin, Xu, Fang-Xiao, Wang, De-Juan, Shen, En-Wei, Cai, Xin-Yu, Wang, Yin, Wang, Na, Ji, Sheng-Jian, Chen, Wei, Schonewille, Martijn, Zhu, J Julius, De Zeeuw, Chris I, Shen, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171863/
https://www.ncbi.nlm.nih.gov/pubmed/37159499
http://dx.doi.org/10.7554/eLife.80875

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