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Risk factors of recurrence in TNM stage I colorectal cancer
PURPOSE: TNM stage I colorectal cancer (CRC) can recur, although the recurrence rate is low. Few studies have evaluated the risk factors for TNM stage I CRC recurrence. This study aimed to evaluate the TNM stage I CRC recurrence rate, as well as risk factors for recurrence. METHODS: In this retrospe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Surgical Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172029/ https://www.ncbi.nlm.nih.gov/pubmed/37179701 http://dx.doi.org/10.4174/astr.2023.104.5.281 |
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author | Paik, Jin-Hee Ryu, Chun-Geun Hwang, Dae-Yong |
author_facet | Paik, Jin-Hee Ryu, Chun-Geun Hwang, Dae-Yong |
author_sort | Paik, Jin-Hee |
collection | PubMed |
description | PURPOSE: TNM stage I colorectal cancer (CRC) can recur, although the recurrence rate is low. Few studies have evaluated the risk factors for TNM stage I CRC recurrence. This study aimed to evaluate the TNM stage I CRC recurrence rate, as well as risk factors for recurrence. METHODS: In this retrospective study, we reviewed the database of patients who had undergone surgery for TNM stage I CRC between November 2008 and December 2014 without receiving neoadjuvant therapy or transanal excision for rectal cancer. Our analysis included 173 patients. Primary lesions were found in the colon of 133 patients and in the rectum of 40 patients. RESULTS: The CRC recurrence rate was 2.9% (5 out of 173 patients). For colon cancer patients, tumor size was not associated with higher recurrence risk (P = 0.098). However, for rectal cancer patients, both tumor size (≥3 cm) and T stage were associated with higher recurrence risk (P = 0.046 and P = 0.046, respectively). Of the 5 recurrent cases, 1 patient exhibited disease progression despite treatment, 1 patient maintained stable disease status after recurrence treatment, and 3 patients had no evidence of a tumor after recurrence treatment. CONCLUSION: Our findings suggest that tumor size and T stage are predictors of stage I rectal cancer recurrence, and careful monitoring and follow-up of patients with larger tumors may be warranted. |
format | Online Article Text |
id | pubmed-10172029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Surgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101720292023-05-12 Risk factors of recurrence in TNM stage I colorectal cancer Paik, Jin-Hee Ryu, Chun-Geun Hwang, Dae-Yong Ann Surg Treat Res Original Article PURPOSE: TNM stage I colorectal cancer (CRC) can recur, although the recurrence rate is low. Few studies have evaluated the risk factors for TNM stage I CRC recurrence. This study aimed to evaluate the TNM stage I CRC recurrence rate, as well as risk factors for recurrence. METHODS: In this retrospective study, we reviewed the database of patients who had undergone surgery for TNM stage I CRC between November 2008 and December 2014 without receiving neoadjuvant therapy or transanal excision for rectal cancer. Our analysis included 173 patients. Primary lesions were found in the colon of 133 patients and in the rectum of 40 patients. RESULTS: The CRC recurrence rate was 2.9% (5 out of 173 patients). For colon cancer patients, tumor size was not associated with higher recurrence risk (P = 0.098). However, for rectal cancer patients, both tumor size (≥3 cm) and T stage were associated with higher recurrence risk (P = 0.046 and P = 0.046, respectively). Of the 5 recurrent cases, 1 patient exhibited disease progression despite treatment, 1 patient maintained stable disease status after recurrence treatment, and 3 patients had no evidence of a tumor after recurrence treatment. CONCLUSION: Our findings suggest that tumor size and T stage are predictors of stage I rectal cancer recurrence, and careful monitoring and follow-up of patients with larger tumors may be warranted. The Korean Surgical Society 2023-05 2023-04-28 /pmc/articles/PMC10172029/ /pubmed/37179701 http://dx.doi.org/10.4174/astr.2023.104.5.281 Text en Copyright © 2023, the Korean Surgical Society https://creativecommons.org/licenses/by-nc/4.0/Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Paik, Jin-Hee Ryu, Chun-Geun Hwang, Dae-Yong Risk factors of recurrence in TNM stage I colorectal cancer |
title | Risk factors of recurrence in TNM stage I colorectal cancer |
title_full | Risk factors of recurrence in TNM stage I colorectal cancer |
title_fullStr | Risk factors of recurrence in TNM stage I colorectal cancer |
title_full_unstemmed | Risk factors of recurrence in TNM stage I colorectal cancer |
title_short | Risk factors of recurrence in TNM stage I colorectal cancer |
title_sort | risk factors of recurrence in tnm stage i colorectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172029/ https://www.ncbi.nlm.nih.gov/pubmed/37179701 http://dx.doi.org/10.4174/astr.2023.104.5.281 |
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