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Risk factors of recurrence in TNM stage I colorectal cancer

PURPOSE: TNM stage I colorectal cancer (CRC) can recur, although the recurrence rate is low. Few studies have evaluated the risk factors for TNM stage I CRC recurrence. This study aimed to evaluate the TNM stage I CRC recurrence rate, as well as risk factors for recurrence. METHODS: In this retrospe...

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Autores principales: Paik, Jin-Hee, Ryu, Chun-Geun, Hwang, Dae-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172029/
https://www.ncbi.nlm.nih.gov/pubmed/37179701
http://dx.doi.org/10.4174/astr.2023.104.5.281
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author Paik, Jin-Hee
Ryu, Chun-Geun
Hwang, Dae-Yong
author_facet Paik, Jin-Hee
Ryu, Chun-Geun
Hwang, Dae-Yong
author_sort Paik, Jin-Hee
collection PubMed
description PURPOSE: TNM stage I colorectal cancer (CRC) can recur, although the recurrence rate is low. Few studies have evaluated the risk factors for TNM stage I CRC recurrence. This study aimed to evaluate the TNM stage I CRC recurrence rate, as well as risk factors for recurrence. METHODS: In this retrospective study, we reviewed the database of patients who had undergone surgery for TNM stage I CRC between November 2008 and December 2014 without receiving neoadjuvant therapy or transanal excision for rectal cancer. Our analysis included 173 patients. Primary lesions were found in the colon of 133 patients and in the rectum of 40 patients. RESULTS: The CRC recurrence rate was 2.9% (5 out of 173 patients). For colon cancer patients, tumor size was not associated with higher recurrence risk (P = 0.098). However, for rectal cancer patients, both tumor size (≥3 cm) and T stage were associated with higher recurrence risk (P = 0.046 and P = 0.046, respectively). Of the 5 recurrent cases, 1 patient exhibited disease progression despite treatment, 1 patient maintained stable disease status after recurrence treatment, and 3 patients had no evidence of a tumor after recurrence treatment. CONCLUSION: Our findings suggest that tumor size and T stage are predictors of stage I rectal cancer recurrence, and careful monitoring and follow-up of patients with larger tumors may be warranted.
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spelling pubmed-101720292023-05-12 Risk factors of recurrence in TNM stage I colorectal cancer Paik, Jin-Hee Ryu, Chun-Geun Hwang, Dae-Yong Ann Surg Treat Res Original Article PURPOSE: TNM stage I colorectal cancer (CRC) can recur, although the recurrence rate is low. Few studies have evaluated the risk factors for TNM stage I CRC recurrence. This study aimed to evaluate the TNM stage I CRC recurrence rate, as well as risk factors for recurrence. METHODS: In this retrospective study, we reviewed the database of patients who had undergone surgery for TNM stage I CRC between November 2008 and December 2014 without receiving neoadjuvant therapy or transanal excision for rectal cancer. Our analysis included 173 patients. Primary lesions were found in the colon of 133 patients and in the rectum of 40 patients. RESULTS: The CRC recurrence rate was 2.9% (5 out of 173 patients). For colon cancer patients, tumor size was not associated with higher recurrence risk (P = 0.098). However, for rectal cancer patients, both tumor size (≥3 cm) and T stage were associated with higher recurrence risk (P = 0.046 and P = 0.046, respectively). Of the 5 recurrent cases, 1 patient exhibited disease progression despite treatment, 1 patient maintained stable disease status after recurrence treatment, and 3 patients had no evidence of a tumor after recurrence treatment. CONCLUSION: Our findings suggest that tumor size and T stage are predictors of stage I rectal cancer recurrence, and careful monitoring and follow-up of patients with larger tumors may be warranted. The Korean Surgical Society 2023-05 2023-04-28 /pmc/articles/PMC10172029/ /pubmed/37179701 http://dx.doi.org/10.4174/astr.2023.104.5.281 Text en Copyright © 2023, the Korean Surgical Society https://creativecommons.org/licenses/by-nc/4.0/Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Paik, Jin-Hee
Ryu, Chun-Geun
Hwang, Dae-Yong
Risk factors of recurrence in TNM stage I colorectal cancer
title Risk factors of recurrence in TNM stage I colorectal cancer
title_full Risk factors of recurrence in TNM stage I colorectal cancer
title_fullStr Risk factors of recurrence in TNM stage I colorectal cancer
title_full_unstemmed Risk factors of recurrence in TNM stage I colorectal cancer
title_short Risk factors of recurrence in TNM stage I colorectal cancer
title_sort risk factors of recurrence in tnm stage i colorectal cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172029/
https://www.ncbi.nlm.nih.gov/pubmed/37179701
http://dx.doi.org/10.4174/astr.2023.104.5.281
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