Perinatal exposure to UDCA prevents neonatal cholestasis in Cyp2c70(-/-) mice with human-like bile acids

BACKGROUND: Cyp2c70(-/-) mice with a human-like bile acid (BA) composition display features of neonatal cholestasis. We assessed whether perinatal ursodeoxycholic acid (UDCA) exposure prevents neonatal cholestasis in Cyp2c70(-/-) mice and reduces cholangiopathy development later in life. METHODS: Cy...

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Detalles Bibliográficos
Autores principales: de Vries, Hilde D., Palmiotti, Anna, Li, Rumei, Hovingh, Milaine V., Mulder, Niels L., Koehorst, Martijn, Bloks, Vincent W., van Zutphen, Tim, Kuipers, Folkert, de Boer, Jan Freark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Basic Science Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172110/
https://www.ncbi.nlm.nih.gov/pubmed/36151295
http://dx.doi.org/10.1038/s41390-022-02303-5

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