Cargando…

Learnable latent embeddings for joint behavioural and neural analysis

Mapping behavioural actions to neural activity is a fundamental goal of neuroscience. As our ability to record large neural and behavioural data increases, there is growing interest in modelling neural dynamics during adaptive behaviours to probe neural representations(1–3). In particular, although...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider, Steffen, Lee, Jin Hwa, Mathis, Mackenzie Weygandt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172131/
https://www.ncbi.nlm.nih.gov/pubmed/37138088
http://dx.doi.org/10.1038/s41586-023-06031-6
_version_ 1785039558304333824
author Schneider, Steffen
Lee, Jin Hwa
Mathis, Mackenzie Weygandt
author_facet Schneider, Steffen
Lee, Jin Hwa
Mathis, Mackenzie Weygandt
author_sort Schneider, Steffen
collection PubMed
description Mapping behavioural actions to neural activity is a fundamental goal of neuroscience. As our ability to record large neural and behavioural data increases, there is growing interest in modelling neural dynamics during adaptive behaviours to probe neural representations(1–3). In particular, although neural latent embeddings can reveal underlying correlates of behaviour, we lack nonlinear techniques that can explicitly and flexibly leverage joint behaviour and neural data to uncover neural dynamics(3–5). Here, we fill this gap with a new encoding method, CEBRA, that jointly uses behavioural and neural data in a (supervised) hypothesis- or (self-supervised) discovery-driven manner to produce both consistent and high-performance latent spaces. We show that consistency can be used as a metric for uncovering meaningful differences, and the inferred latents can be used for decoding. We validate its accuracy and demonstrate our tool’s utility for both calcium and electrophysiology datasets, across sensory and motor tasks and in simple or complex behaviours across species. It allows leverage of single- and multi-session datasets for hypothesis testing or can be used label free. Lastly, we show that CEBRA can be used for the mapping of space, uncovering complex kinematic features, for the production of consistent latent spaces across two-photon and Neuropixels data, and can provide rapid, high-accuracy decoding of natural videos from visual cortex.
format Online
Article
Text
id pubmed-10172131
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-101721312023-05-12 Learnable latent embeddings for joint behavioural and neural analysis Schneider, Steffen Lee, Jin Hwa Mathis, Mackenzie Weygandt Nature Article Mapping behavioural actions to neural activity is a fundamental goal of neuroscience. As our ability to record large neural and behavioural data increases, there is growing interest in modelling neural dynamics during adaptive behaviours to probe neural representations(1–3). In particular, although neural latent embeddings can reveal underlying correlates of behaviour, we lack nonlinear techniques that can explicitly and flexibly leverage joint behaviour and neural data to uncover neural dynamics(3–5). Here, we fill this gap with a new encoding method, CEBRA, that jointly uses behavioural and neural data in a (supervised) hypothesis- or (self-supervised) discovery-driven manner to produce both consistent and high-performance latent spaces. We show that consistency can be used as a metric for uncovering meaningful differences, and the inferred latents can be used for decoding. We validate its accuracy and demonstrate our tool’s utility for both calcium and electrophysiology datasets, across sensory and motor tasks and in simple or complex behaviours across species. It allows leverage of single- and multi-session datasets for hypothesis testing or can be used label free. Lastly, we show that CEBRA can be used for the mapping of space, uncovering complex kinematic features, for the production of consistent latent spaces across two-photon and Neuropixels data, and can provide rapid, high-accuracy decoding of natural videos from visual cortex. Nature Publishing Group UK 2023-05-03 2023 /pmc/articles/PMC10172131/ /pubmed/37138088 http://dx.doi.org/10.1038/s41586-023-06031-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Schneider, Steffen
Lee, Jin Hwa
Mathis, Mackenzie Weygandt
Learnable latent embeddings for joint behavioural and neural analysis
title Learnable latent embeddings for joint behavioural and neural analysis
title_full Learnable latent embeddings for joint behavioural and neural analysis
title_fullStr Learnable latent embeddings for joint behavioural and neural analysis
title_full_unstemmed Learnable latent embeddings for joint behavioural and neural analysis
title_short Learnable latent embeddings for joint behavioural and neural analysis
title_sort learnable latent embeddings for joint behavioural and neural analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172131/
https://www.ncbi.nlm.nih.gov/pubmed/37138088
http://dx.doi.org/10.1038/s41586-023-06031-6
work_keys_str_mv AT schneidersteffen learnablelatentembeddingsforjointbehaviouralandneuralanalysis
AT leejinhwa learnablelatentembeddingsforjointbehaviouralandneuralanalysis
AT mathismackenzieweygandt learnablelatentembeddingsforjointbehaviouralandneuralanalysis