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Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome
Polycystic ovarian syndrome (PCOS) is a complicated endocrinopathy with an unclear etiology that afflicts fertility status in women. Although the underlying causes and pathophysiology of PCOS are not completely understood, it is suspected to be driven by environmental factors as well as genetic and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172238/ https://www.ncbi.nlm.nih.gov/pubmed/37060405 http://dx.doi.org/10.1007/s11356-023-26820-w |
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author | Prabhu, Navya B. Vasishta, Sampara Bhat, Shashikala K. Joshi, Manjunath B. Kabekkodu, Shama Prasada Satyamoorthy, Kapaettu Rai, Padmalatha S. |
author_facet | Prabhu, Navya B. Vasishta, Sampara Bhat, Shashikala K. Joshi, Manjunath B. Kabekkodu, Shama Prasada Satyamoorthy, Kapaettu Rai, Padmalatha S. |
author_sort | Prabhu, Navya B. |
collection | PubMed |
description | Polycystic ovarian syndrome (PCOS) is a complicated endocrinopathy with an unclear etiology that afflicts fertility status in women. Although the underlying causes and pathophysiology of PCOS are not completely understood, it is suspected to be driven by environmental factors as well as genetic and epigenetic factors. Bisphenol A (BPA) is a weak estrogenic endocrine disruptor known to cause adverse reproductive outcomes in women. A growing relevance supports the notion that BPA may contribute to PCOS pathogenesis. Due to the indeterminate molecular mechanisms of BPA in PCOS endocrinopathy, we sought liquid chromatography with tandem mass spectrometry (LC–MS/MS), a metabolomics strategy that could generate a metabolic signature based on urinary BPA levels of PCOS and healthy individuals. Towards this, we examined urinary BPA levels in PCOS and healthy women by ELISA and performed univariate and chemometric analysis to distinguish metabolic patterns among high and low BPA in PCOS and healthy females, followed by pathway and biomarker analysis employing MetaboAnalyst 5.0. Our findings indicated aberrant levels of certain steroids, sphingolipids, and others, implying considerable disturbances in steroid hormone biosynthesis, linoleic, linolenic, sphingolipid metabolism, and various other pathways across target groups in comparison to healthy women with low BPA levels. Collectively, our findings provide insight into metabolic signatures of BPA-exposed PCOS women, which can potentially improve management strategies and precision medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-023-26820-w. |
format | Online Article Text |
id | pubmed-10172238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-101722382023-05-12 Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome Prabhu, Navya B. Vasishta, Sampara Bhat, Shashikala K. Joshi, Manjunath B. Kabekkodu, Shama Prasada Satyamoorthy, Kapaettu Rai, Padmalatha S. Environ Sci Pollut Res Int Research Article Polycystic ovarian syndrome (PCOS) is a complicated endocrinopathy with an unclear etiology that afflicts fertility status in women. Although the underlying causes and pathophysiology of PCOS are not completely understood, it is suspected to be driven by environmental factors as well as genetic and epigenetic factors. Bisphenol A (BPA) is a weak estrogenic endocrine disruptor known to cause adverse reproductive outcomes in women. A growing relevance supports the notion that BPA may contribute to PCOS pathogenesis. Due to the indeterminate molecular mechanisms of BPA in PCOS endocrinopathy, we sought liquid chromatography with tandem mass spectrometry (LC–MS/MS), a metabolomics strategy that could generate a metabolic signature based on urinary BPA levels of PCOS and healthy individuals. Towards this, we examined urinary BPA levels in PCOS and healthy women by ELISA and performed univariate and chemometric analysis to distinguish metabolic patterns among high and low BPA in PCOS and healthy females, followed by pathway and biomarker analysis employing MetaboAnalyst 5.0. Our findings indicated aberrant levels of certain steroids, sphingolipids, and others, implying considerable disturbances in steroid hormone biosynthesis, linoleic, linolenic, sphingolipid metabolism, and various other pathways across target groups in comparison to healthy women with low BPA levels. Collectively, our findings provide insight into metabolic signatures of BPA-exposed PCOS women, which can potentially improve management strategies and precision medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11356-023-26820-w. Springer Berlin Heidelberg 2023-04-15 2023 /pmc/articles/PMC10172238/ /pubmed/37060405 http://dx.doi.org/10.1007/s11356-023-26820-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Prabhu, Navya B. Vasishta, Sampara Bhat, Shashikala K. Joshi, Manjunath B. Kabekkodu, Shama Prasada Satyamoorthy, Kapaettu Rai, Padmalatha S. Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome |
title | Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome |
title_full | Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome |
title_fullStr | Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome |
title_full_unstemmed | Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome |
title_short | Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome |
title_sort | distinct metabolic signatures in blood plasma of bisphenol a–exposed women with polycystic ovarian syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172238/ https://www.ncbi.nlm.nih.gov/pubmed/37060405 http://dx.doi.org/10.1007/s11356-023-26820-w |
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