Immuno-PET Monitoring of CD8(+) T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a (89)Zr Anti-CD8(+) Mouse Minibody in EMT6 Syngeneic Tumor Mouse

PURPOSE: The presence and functional competence of intratumoral CD8(+) T cells is often a barometer for successful immunotherapeutic responses in cancer. Despite this understanding and the extensive number of clinical-stage immunotherapies focused on potentiation (co-stimulation) or rescue (checkpoi...

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Detalles Bibliográficos
Autores principales: Alsaid, Hasan, Cheng, Shih-Hsun, Bi, Meixia, Xie, Fang, Rambo, Mary, Skedzielewski, Tinamarie, Hoang, Bao, Mohanan, Sunish, Comroe, Debra, Gehman, Andrew, Hsu, Chih-Yang, Farhangi, Kamyar, Tran, Hoang, Sherina, Valeriia, Doan, Minh, Groseclose, M. Reid, Hopson, Christopher B., Brett, Sara, Wilson, Ian A., Nicholls, Andrew, Ballas, Marc, Waight, Jeremy D., Jucker, Beat M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172244/
https://www.ncbi.nlm.nih.gov/pubmed/36266600
http://dx.doi.org/10.1007/s11307-022-01781-7

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