It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3

The occurrence of NO/cGMP signalling in cardiac cells is a matter of debate. Recent measurements with a FRET-based cGMP indicator in isolated cardiac cells revealed NO-induced cGMP signals in cardiac fibroblasts while cardiomyocytes were devoid of these signals. In a fibroblast/myocyte co-culture mo...

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Detalles Bibliográficos
Autores principales: Menges, Lukas, Giesen, Jan, Yilmaz, Kerem, Mergia, Evanthia, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Koesling, Doris, Russwurm, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172304/
https://www.ncbi.nlm.nih.gov/pubmed/37165086
http://dx.doi.org/10.1038/s42003-023-04880-5

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