Cargando…

Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program

Pregnant women’s perspectives should be included in the dialogue surrounding the expanding offers of non-invasive prenatal testing (NIPT), especially now that technological possibilities are rapidly increasing. This study evaluated women’s experiences with the offer of genome-wide (GW) first-tier NI...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Meij, Karuna R. M., van de Pol, Qiu Ying. F., Bekker, Mireille N., Martin, Linda, Gitsels-van der Wal, Janneke, van Vliet-Lachotzki, Elsbeth H., Weiss, Janneke M., Galjaard, Robert-Jan H., Sistermans, Erik A., Macville, Merryn V. E., Henneman, Lidewij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172316/
https://www.ncbi.nlm.nih.gov/pubmed/36481825
http://dx.doi.org/10.1038/s41431-022-01248-x
_version_ 1785039597323943936
author van der Meij, Karuna R. M.
van de Pol, Qiu Ying. F.
Bekker, Mireille N.
Martin, Linda
Gitsels-van der Wal, Janneke
van Vliet-Lachotzki, Elsbeth H.
Weiss, Janneke M.
Galjaard, Robert-Jan H.
Sistermans, Erik A.
Macville, Merryn V. E.
Henneman, Lidewij
author_facet van der Meij, Karuna R. M.
van de Pol, Qiu Ying. F.
Bekker, Mireille N.
Martin, Linda
Gitsels-van der Wal, Janneke
van Vliet-Lachotzki, Elsbeth H.
Weiss, Janneke M.
Galjaard, Robert-Jan H.
Sistermans, Erik A.
Macville, Merryn V. E.
Henneman, Lidewij
author_sort van der Meij, Karuna R. M.
collection PubMed
description Pregnant women’s perspectives should be included in the dialogue surrounding the expanding offers of non-invasive prenatal testing (NIPT), especially now that technological possibilities are rapidly increasing. This study evaluated women’s experiences with the offer of genome-wide (GW) first-tier NIPT in a national screening program. A nationwide pre-and post-test questionnaire was completed by 473 pregnant women choosing between targeted NIPT (trisomies 21, 18 and 13 only) and GW-NIPT (also other findings) within the Dutch TRIDENT-2 study. Measures included satisfaction, reasons for or against choosing GW-NIPT, anxiety, and opinion on the future scope of NIPT. Most respondents (90.4%) were glad to have been offered the choice between GW-NIPT and targeted NIPT; 76.5% chose GW-NIPT. Main reasons to choose GW-NIPT were ‘wanting as much information as possible regarding the child’s health’ (38.6%) and ‘to be prepared for everything’ (23.8%). Main reasons to choose targeted NIPT were ‘avoiding uncertain results/outcomes’ (33.7%) and ‘not wanting to unnecessarily worry’ (32.6%). Nearly all respondents received a low-risk NIPT result (98.7%). No differences were found in anxiety between women choosing GW-NIPT and targeted NIPT. Most respondents were favorable toward future prenatal screening for a range of conditions, including life-threatening disorders, mental disabilities, disorders treatable in pregnancy and severe physical disabilities, regardless of their choice for GW-NIPT or targeted NIPT. In conclusion, women who chose first-tier NIPT were satisfied with the choice between GW-NIPT and targeted NIPT, and most women were favorable toward a broader future screening offer. Our results contribute to the debate concerning the expansion of NIPT.
format Online
Article
Text
id pubmed-10172316
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-101723162023-05-12 Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program van der Meij, Karuna R. M. van de Pol, Qiu Ying. F. Bekker, Mireille N. Martin, Linda Gitsels-van der Wal, Janneke van Vliet-Lachotzki, Elsbeth H. Weiss, Janneke M. Galjaard, Robert-Jan H. Sistermans, Erik A. Macville, Merryn V. E. Henneman, Lidewij Eur J Hum Genet Article Pregnant women’s perspectives should be included in the dialogue surrounding the expanding offers of non-invasive prenatal testing (NIPT), especially now that technological possibilities are rapidly increasing. This study evaluated women’s experiences with the offer of genome-wide (GW) first-tier NIPT in a national screening program. A nationwide pre-and post-test questionnaire was completed by 473 pregnant women choosing between targeted NIPT (trisomies 21, 18 and 13 only) and GW-NIPT (also other findings) within the Dutch TRIDENT-2 study. Measures included satisfaction, reasons for or against choosing GW-NIPT, anxiety, and opinion on the future scope of NIPT. Most respondents (90.4%) were glad to have been offered the choice between GW-NIPT and targeted NIPT; 76.5% chose GW-NIPT. Main reasons to choose GW-NIPT were ‘wanting as much information as possible regarding the child’s health’ (38.6%) and ‘to be prepared for everything’ (23.8%). Main reasons to choose targeted NIPT were ‘avoiding uncertain results/outcomes’ (33.7%) and ‘not wanting to unnecessarily worry’ (32.6%). Nearly all respondents received a low-risk NIPT result (98.7%). No differences were found in anxiety between women choosing GW-NIPT and targeted NIPT. Most respondents were favorable toward future prenatal screening for a range of conditions, including life-threatening disorders, mental disabilities, disorders treatable in pregnancy and severe physical disabilities, regardless of their choice for GW-NIPT or targeted NIPT. In conclusion, women who chose first-tier NIPT were satisfied with the choice between GW-NIPT and targeted NIPT, and most women were favorable toward a broader future screening offer. Our results contribute to the debate concerning the expansion of NIPT. Springer International Publishing 2022-12-09 2023-05 /pmc/articles/PMC10172316/ /pubmed/36481825 http://dx.doi.org/10.1038/s41431-022-01248-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
van der Meij, Karuna R. M.
van de Pol, Qiu Ying. F.
Bekker, Mireille N.
Martin, Linda
Gitsels-van der Wal, Janneke
van Vliet-Lachotzki, Elsbeth H.
Weiss, Janneke M.
Galjaard, Robert-Jan H.
Sistermans, Erik A.
Macville, Merryn V. E.
Henneman, Lidewij
Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
title Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
title_full Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
title_fullStr Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
title_full_unstemmed Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
title_short Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
title_sort experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172316/
https://www.ncbi.nlm.nih.gov/pubmed/36481825
http://dx.doi.org/10.1038/s41431-022-01248-x
work_keys_str_mv AT vandermeijkarunarm experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT vandepolqiuyingf experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT bekkermireillen experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT martinlinda experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT gitselsvanderwaljanneke experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT vanvlietlachotzkielsbethh experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT weissjannekem experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT galjaardrobertjanh experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT sistermanserika experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT macvillemerrynve experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT hennemanlidewij experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram
AT experiencesofpregnantwomenwithgenomewidenoninvasiveprenataltestinginanationalscreeningprogram