Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe the Schlafen 12 protein (SLFN12) as an HIV-1 restriction factor that establishes a post-transcript...

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Detalles Bibliográficos
Autores principales: Kobayashi-Ishihara, Mie, Frazão Smutná, Katarína, Alonso, Florencia E., Argilaguet, Jordi, Esteve-Codina, Anna, Geiger, Kerstin, Genescà, Meritxell, Grau-Expósito, Judith, Duran-Castells, Clara, Rogenmoser, Selina, Böttcher, René, Jungfleisch, Jennifer, Oliva, Baldomero, Martinez, Javier P., Li, Manqing, David, Michael, Yamagishi, Makoto, Ruiz-Riol, Marta, Brander, Christian, Tsunetsugu-Yokota, Yasuko, Buzon, Maria J., Díez, Juana, Meyerhans, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172343/
https://www.ncbi.nlm.nih.gov/pubmed/37165099
http://dx.doi.org/10.1038/s42003-023-04841-y

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