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Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are immunomodulatory steroids that can suppress inflammation. Their anti-inflammatory properties within tissues are influenced by their pre-recept...

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Detalles Bibliográficos
Autores principales:	Mahida, Rahul Y., Lax, Siân, Bassford, Christopher R., Scott, Aaron, Parekh, Dhruv, Hardy, Rowan S., Naidu, Babu, Matthay, Michael A., Stewart, Paul M., Cooper, Mark C., Perkins, Gavin D., Thickett, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172463/ https://www.ncbi.nlm.nih.gov/pubmed/37180160 http://dx.doi.org/10.3389/fimmu.2023.1159831

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