SARS-CoV-2 infection dysregulates the expression of clinically relevant drug metabolizing enzymes in Vero E6 cells and membrane transporters in human lung tissues

SARS-CoV-2-mediated interactions with drug metabolizing enzymes and membrane transporters (DMETs) in different tissues, especially lung, the main affected organ may limit the clinical efficacy and safety profile of promising COVID-19 drugs. Herein, we investigated whether SARS-CoV-2 infection could...

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Detalles Bibliográficos
Autores principales: Nwabufo, Chukwunonso K., Hoque, Md. Tozammel, Yip, Lily, Khara, Maliha, Mubareka, Samira, Pollanen, Michael S., Bendayan, Reina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172598/
https://www.ncbi.nlm.nih.gov/pubmed/37180730
http://dx.doi.org/10.3389/fphar.2023.1124693

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