Cargando…
Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review
BACKGROUND: Inheritance patterns show familial clustering of gastrointestinal cancers, and multiple germline conditions have now been identified that predispose to colorectal, gastric, and pancreatic cancers. METHODS: A narrative review based on recent relevant literature was conducted. RESULTS: Lyn...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172688/ https://www.ncbi.nlm.nih.gov/pubmed/37165697 http://dx.doi.org/10.1093/bjsopen/zrad023 |
_version_ | 1785039664798760960 |
---|---|
author | Seppälä, Toni T Burkhart, Richard A Katona, Bryson W |
author_facet | Seppälä, Toni T Burkhart, Richard A Katona, Bryson W |
author_sort | Seppälä, Toni T |
collection | PubMed |
description | BACKGROUND: Inheritance patterns show familial clustering of gastrointestinal cancers, and multiple germline conditions have now been identified that predispose to colorectal, gastric, and pancreatic cancers. METHODS: A narrative review based on recent relevant literature was conducted. RESULTS: Lynch syndrome, formerly known as hereditary non-polyposis colorectal cancer, increases the risk of several abdominal cancers, with the highest population prevalence. Familial adenomatous polyposis and some of the more infrequent polyposis syndromes have distinct characteristics affecting various organ-specific cancer risks. Hereditary gastric and pancreatic cancer syndromes include those also causing colorectal cancer, while additional genetic disorders predisposing only to upper gastrointestinal malignancies have been recognized more recently. Diagnosing and managing hereditary cancer syndromes requires multidisciplinary expertise and may be best managed in tertiary centres, with a need to consider patient preference and ensure shared decision-making. CONCLUSION: Several germline conditions predispose to colorectal, gastric, and pancreatic cancer, which inform identification, surveillance regimens, prevention, cascade screening, counselling, and surgical management. The authors describe developments in the hereditary origin of colorectal, gastric, and pancreatic cancer with current recommendations in surveillance and surgical management. |
format | Online Article Text |
id | pubmed-10172688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-101726882023-05-12 Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review Seppälä, Toni T Burkhart, Richard A Katona, Bryson W BJS Open Review Article BACKGROUND: Inheritance patterns show familial clustering of gastrointestinal cancers, and multiple germline conditions have now been identified that predispose to colorectal, gastric, and pancreatic cancers. METHODS: A narrative review based on recent relevant literature was conducted. RESULTS: Lynch syndrome, formerly known as hereditary non-polyposis colorectal cancer, increases the risk of several abdominal cancers, with the highest population prevalence. Familial adenomatous polyposis and some of the more infrequent polyposis syndromes have distinct characteristics affecting various organ-specific cancer risks. Hereditary gastric and pancreatic cancer syndromes include those also causing colorectal cancer, while additional genetic disorders predisposing only to upper gastrointestinal malignancies have been recognized more recently. Diagnosing and managing hereditary cancer syndromes requires multidisciplinary expertise and may be best managed in tertiary centres, with a need to consider patient preference and ensure shared decision-making. CONCLUSION: Several germline conditions predispose to colorectal, gastric, and pancreatic cancer, which inform identification, surveillance regimens, prevention, cascade screening, counselling, and surgical management. The authors describe developments in the hereditary origin of colorectal, gastric, and pancreatic cancer with current recommendations in surveillance and surgical management. Oxford University Press 2023-05-10 /pmc/articles/PMC10172688/ /pubmed/37165697 http://dx.doi.org/10.1093/bjsopen/zrad023 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Seppälä, Toni T Burkhart, Richard A Katona, Bryson W Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
title | Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
title_full | Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
title_fullStr | Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
title_full_unstemmed | Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
title_short | Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
title_sort | hereditary colorectal, gastric, and pancreatic cancer: comprehensive review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172688/ https://www.ncbi.nlm.nih.gov/pubmed/37165697 http://dx.doi.org/10.1093/bjsopen/zrad023 |
work_keys_str_mv | AT seppalatonit hereditarycolorectalgastricandpancreaticcancercomprehensivereview AT burkhartricharda hereditarycolorectalgastricandpancreaticcancercomprehensivereview AT katonabrysonw hereditarycolorectalgastricandpancreaticcancercomprehensivereview |