Cargando…

Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro

Herpes simplex virus type 2 (HSV-2) is a human infectious agent with significant impact on public health due to its high prevalence in the population and its ability to elicit a wide range of diseases, from mild to severe. Although several antiviral drugs, such as acyclovir, are currently available...

Descripción completa

Detalles Bibliográficos
Autores principales: Henríquez, Adolfo, Vargas, Juan Pablo, Landahur, Chris, Corrales, Nicolás, Agurto-Muñoz, Andrés, González, Pablo A., Agurto-Muñoz, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172717/
https://www.ncbi.nlm.nih.gov/pubmed/37181274
http://dx.doi.org/10.1016/j.btre.2023.e00798
_version_ 1785039671649107968
author Henríquez, Adolfo
Vargas, Juan Pablo
Landahur, Chris
Corrales, Nicolás
Agurto-Muñoz, Andrés
González, Pablo A.
Agurto-Muñoz, Cristian
author_facet Henríquez, Adolfo
Vargas, Juan Pablo
Landahur, Chris
Corrales, Nicolás
Agurto-Muñoz, Andrés
González, Pablo A.
Agurto-Muñoz, Cristian
author_sort Henríquez, Adolfo
collection PubMed
description Herpes simplex virus type 2 (HSV-2) is a human infectious agent with significant impact on public health due to its high prevalence in the population and its ability to elicit a wide range of diseases, from mild to severe. Although several antiviral drugs, such as acyclovir, are currently available to treat HSV-2-related clinical manifestations, their effectiveness is poor. Therefore, the identification and development of new antiviral drugs against HSV-2 is necessary. Seaweeds are attractive candidates for such purposes because they are a vast source of natural products due to their highly diverse compounds, many with demonstrated biological activity. In this study, we evaluated the in vitro antiviral potential of red algae extracts obtained from Agarophyton chilense, Mazzaella laminarioides, Porphyridium cruentum, and Porphyridium purpureum against HSV-2. The phycocolloids agar and carrageenan obtained from the macroalgae dry biomass of A. chilense and M. laminarioides and the exopolysaccharides from P. cruentum and P. purpureum were evaluated. The cytotoxicity of these extracts and the surpluses obtained in the extraction process of the agar and carrageenans were evaluated in human epithelial cells (HeLa cells) in addition to their antiviral activity against HSV-2, which were used to calculate selectivity indexes (SIs). Several compounds displayed antiviral activity against HSV-2, but carrageenans were not considered as a potential antiviral therapeutic agent when compared to the other algae extracts with a SI of 23.3. Future assays in vivo models for HSV-2 infection should reveal the therapeutic potential of these algae compounds as new antivirals against this virus.
format Online
Article
Text
id pubmed-10172717
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-101727172023-05-12 Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro Henríquez, Adolfo Vargas, Juan Pablo Landahur, Chris Corrales, Nicolás Agurto-Muñoz, Andrés González, Pablo A. Agurto-Muñoz, Cristian Biotechnol Rep (Amst) Research Article Herpes simplex virus type 2 (HSV-2) is a human infectious agent with significant impact on public health due to its high prevalence in the population and its ability to elicit a wide range of diseases, from mild to severe. Although several antiviral drugs, such as acyclovir, are currently available to treat HSV-2-related clinical manifestations, their effectiveness is poor. Therefore, the identification and development of new antiviral drugs against HSV-2 is necessary. Seaweeds are attractive candidates for such purposes because they are a vast source of natural products due to their highly diverse compounds, many with demonstrated biological activity. In this study, we evaluated the in vitro antiviral potential of red algae extracts obtained from Agarophyton chilense, Mazzaella laminarioides, Porphyridium cruentum, and Porphyridium purpureum against HSV-2. The phycocolloids agar and carrageenan obtained from the macroalgae dry biomass of A. chilense and M. laminarioides and the exopolysaccharides from P. cruentum and P. purpureum were evaluated. The cytotoxicity of these extracts and the surpluses obtained in the extraction process of the agar and carrageenans were evaluated in human epithelial cells (HeLa cells) in addition to their antiviral activity against HSV-2, which were used to calculate selectivity indexes (SIs). Several compounds displayed antiviral activity against HSV-2, but carrageenans were not considered as a potential antiviral therapeutic agent when compared to the other algae extracts with a SI of 23.3. Future assays in vivo models for HSV-2 infection should reveal the therapeutic potential of these algae compounds as new antivirals against this virus. Elsevier 2023-04-23 /pmc/articles/PMC10172717/ /pubmed/37181274 http://dx.doi.org/10.1016/j.btre.2023.e00798 Text en © 2023 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Henríquez, Adolfo
Vargas, Juan Pablo
Landahur, Chris
Corrales, Nicolás
Agurto-Muñoz, Andrés
González, Pablo A.
Agurto-Muñoz, Cristian
Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
title Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
title_full Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
title_fullStr Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
title_full_unstemmed Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
title_short Antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
title_sort antiviral activity of red algae phycocolloids against herpes simplex virus type 2 in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172717/
https://www.ncbi.nlm.nih.gov/pubmed/37181274
http://dx.doi.org/10.1016/j.btre.2023.e00798
work_keys_str_mv AT henriquezadolfo antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro
AT vargasjuanpablo antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro
AT landahurchris antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro
AT corralesnicolas antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro
AT agurtomunozandres antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro
AT gonzalezpabloa antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro
AT agurtomunozcristian antiviralactivityofredalgaephycocolloidsagainstherpessimplexvirustype2invitro