Cytotoxic CNS-associated T cells drive axon degeneration by targeting perturbed oligodendrocytes in PLP1 mutant mice

Myelin defects lead to neurological dysfunction in various diseases and in normal aging. Chronic neuroinflammation often contributes to axon-myelin damage in these conditions and can be initiated and/or sustained by perturbed myelinating glia. We have previously shown that distinct PLP1 mutations re...

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Detalles Bibliográficos
Autores principales: Abdelwahab, Tassnim, Stadler, David, Knöpper, Konrad, Arampatzi, Panagiota, Saliba, Antoine-Emmanuel, Kastenmüller, Wolfgang, Martini, Rudolf, Groh, Janos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172788/
https://www.ncbi.nlm.nih.gov/pubmed/37182098
http://dx.doi.org/10.1016/j.isci.2023.106698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172788/
https://www.ncbi.nlm.nih.gov/pubmed/37182098
http://dx.doi.org/10.1016/j.isci.2023.106698

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