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Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease
PURPOSE: To evaluate the effect of fluorescein dye usage on renal function in patients with diabetic retinopathy (DR) and chronic kidney disease (CKD). METHODS: Diabetic patients with retinopathy who were candidate for fundus fluorescein angiography (FA) were evaluated for serum creatinine and urea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PUBLISHED BY KNOWLEDGE E
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172804/ https://www.ncbi.nlm.nih.gov/pubmed/37181615 http://dx.doi.org/10.18502/jovr.v18i2.13183 |
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author | Ebrahimiadib, Nazanin Hadavand Mirzaei, Shaghayegh Riazi-Esfahani, Hamid Amini, Manouchehr |
author_facet | Ebrahimiadib, Nazanin Hadavand Mirzaei, Shaghayegh Riazi-Esfahani, Hamid Amini, Manouchehr |
author_sort | Ebrahimiadib, Nazanin |
collection | PubMed |
description | PURPOSE: To evaluate the effect of fluorescein dye usage on renal function in patients with diabetic retinopathy (DR) and chronic kidney disease (CKD). METHODS: Diabetic patients with retinopathy who were candidate for fundus fluorescein angiography (FA) were evaluated for serum creatinine and urea levels within five days prior to performing the FA. Serum creatinine levels of 1.5 mg/dl or more in males and 1.4 mg/dl or more in females were both identified as CKD and were included in the study. An increase of 0.5 mg/dl or 25% in creatinine after FA was considered as contrast-induced acute kidney injury (AKI). Estimated glomerular filtration rate (eGFR) was also calculated for all patients using a CKD-Epi formula. CKD grading was determined based on eGFR values. RESULTS: Forty-two patients agreed to participate, of which 23 (54.8%) were male. Seventeen patients were identified with grade 3a or lower CKD, 12 with grade 3b, 11 with grade 4, and two with grade 5 CKD. Considering all grades of CKD, the mean blood urea before and after angiography was 58.48 [Formula: see text] 26.7 and 57 [Formula: see text] 27.81 mg/dl, respectively (P = 0.475). The mean serum creatinine before and after the test was 1.89 [Formula: see text] 1.04 and 1.87 [Formula: see text] 0.99 mg/dl, respectively (P = 0.993). The mean eGFR before and after the test was 44.024 [Formula: see text] 23.5447 and 43.850 [Formula: see text] 21.8581 mL/min/1.73 m(2) (P = 0.875). CONCLUSION: According to the findings of this study, FA does not seem to further deteriorate kidney function in patients with diabetic associated CKD. |
format | Online Article Text |
id | pubmed-10172804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | PUBLISHED BY KNOWLEDGE E |
record_format | MEDLINE/PubMed |
spelling | pubmed-101728042023-05-12 Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease Ebrahimiadib, Nazanin Hadavand Mirzaei, Shaghayegh Riazi-Esfahani, Hamid Amini, Manouchehr J Ophthalmic Vis Res Original Article PURPOSE: To evaluate the effect of fluorescein dye usage on renal function in patients with diabetic retinopathy (DR) and chronic kidney disease (CKD). METHODS: Diabetic patients with retinopathy who were candidate for fundus fluorescein angiography (FA) were evaluated for serum creatinine and urea levels within five days prior to performing the FA. Serum creatinine levels of 1.5 mg/dl or more in males and 1.4 mg/dl or more in females were both identified as CKD and were included in the study. An increase of 0.5 mg/dl or 25% in creatinine after FA was considered as contrast-induced acute kidney injury (AKI). Estimated glomerular filtration rate (eGFR) was also calculated for all patients using a CKD-Epi formula. CKD grading was determined based on eGFR values. RESULTS: Forty-two patients agreed to participate, of which 23 (54.8%) were male. Seventeen patients were identified with grade 3a or lower CKD, 12 with grade 3b, 11 with grade 4, and two with grade 5 CKD. Considering all grades of CKD, the mean blood urea before and after angiography was 58.48 [Formula: see text] 26.7 and 57 [Formula: see text] 27.81 mg/dl, respectively (P = 0.475). The mean serum creatinine before and after the test was 1.89 [Formula: see text] 1.04 and 1.87 [Formula: see text] 0.99 mg/dl, respectively (P = 0.993). The mean eGFR before and after the test was 44.024 [Formula: see text] 23.5447 and 43.850 [Formula: see text] 21.8581 mL/min/1.73 m(2) (P = 0.875). CONCLUSION: According to the findings of this study, FA does not seem to further deteriorate kidney function in patients with diabetic associated CKD. PUBLISHED BY KNOWLEDGE E 2023-04-19 /pmc/articles/PMC10172804/ /pubmed/37181615 http://dx.doi.org/10.18502/jovr.v18i2.13183 Text en Copyright © 2023 Ebrahimiadib et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ebrahimiadib, Nazanin Hadavand Mirzaei, Shaghayegh Riazi-Esfahani, Hamid Amini, Manouchehr Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease |
title | Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease |
title_full | Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease |
title_fullStr | Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease |
title_full_unstemmed | Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease |
title_short | Renal Function following Fluorescein Angiography in Diabetic Patients with Chronic Kidney Disease |
title_sort | renal function following fluorescein angiography in diabetic patients with chronic kidney disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172804/ https://www.ncbi.nlm.nih.gov/pubmed/37181615 http://dx.doi.org/10.18502/jovr.v18i2.13183 |
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