Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans

We identified the Low-Density Lipoprotein (LDL) Receptor Related Protein-2 (LRP-2) in a RNAi screen for genes that regulate glutamatergic behavior in C. elegans . lrp-2 loss-of-function mutants have defects in glutamatergic mechanosensory nose-touch behavior and suppress increased spontaneous revers...

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Detalles Bibliográficos
Autores principales: Rennich, Bethany J, Luth, Eric S, Hofer, Julia, Juo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172966/
https://www.ncbi.nlm.nih.gov/pubmed/37179968
http://dx.doi.org/10.17912/micropub.biology.000837
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author Rennich, Bethany J
Luth, Eric S
Hofer, Julia
Juo, Peter
author_facet Rennich, Bethany J
Luth, Eric S
Hofer, Julia
Juo, Peter
author_sort Rennich, Bethany J
collection PubMed
description We identified the Low-Density Lipoprotein (LDL) Receptor Related Protein-2 (LRP-2) in a RNAi screen for genes that regulate glutamatergic behavior in C. elegans . lrp-2 loss-of-function mutants have defects in glutamatergic mechanosensory nose-touch behavior and suppress increased spontaneous reversals induced by GLR-1(A/T), a constitutively-active form of the AMPA-type glutamate receptor GLR-1. Total and surface levels of GLR-1 are increased throughout the ventral nerve cord of lrp-2 mutants suggesting that LRP-2 promotes glutamatergic signaling by regulating some aspect of GLR-1 trafficking, localization or function.
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spelling pubmed-101729662023-05-12 Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans Rennich, Bethany J Luth, Eric S Hofer, Julia Juo, Peter MicroPubl Biol New Finding We identified the Low-Density Lipoprotein (LDL) Receptor Related Protein-2 (LRP-2) in a RNAi screen for genes that regulate glutamatergic behavior in C. elegans . lrp-2 loss-of-function mutants have defects in glutamatergic mechanosensory nose-touch behavior and suppress increased spontaneous reversals induced by GLR-1(A/T), a constitutively-active form of the AMPA-type glutamate receptor GLR-1. Total and surface levels of GLR-1 are increased throughout the ventral nerve cord of lrp-2 mutants suggesting that LRP-2 promotes glutamatergic signaling by regulating some aspect of GLR-1 trafficking, localization or function. Caltech Library 2023-04-26 /pmc/articles/PMC10172966/ /pubmed/37179968 http://dx.doi.org/10.17912/micropub.biology.000837 Text en Copyright: © 2023 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Rennich, Bethany J
Luth, Eric S
Hofer, Julia
Juo, Peter
Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans
title Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans
title_full Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans
title_fullStr Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans
title_full_unstemmed Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans
title_short Low-Density Lipoprotein Receptor LRP-2 regulates GLR-1 glutamate receptors and glutamatergic behavior in C. elegans
title_sort low-density lipoprotein receptor lrp-2 regulates glr-1 glutamate receptors and glutamatergic behavior in c. elegans
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10172966/
https://www.ncbi.nlm.nih.gov/pubmed/37179968
http://dx.doi.org/10.17912/micropub.biology.000837
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