Molecular and biologic biomarkers of Ewing sarcoma: A systematic review

With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and young adults. It is not a frequent tumor but is the second most common bone malignancy in children. It has a 5-year survival rate of 65–75%; however, it has a poor prognosis when it relapses in patients. A genomic...

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Detalles Bibliográficos
Autores principales: Daher, Mohammad, Zalaquett, Ziad, Chalhoub, Ralph, Abi Farraj, Sami, Abdo, Majd, Sebaaly, Amer, Kourie, Hampig-Raphaël, Ghanem, Ismat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173001/
https://www.ncbi.nlm.nih.gov/pubmed/37180735
http://dx.doi.org/10.1016/j.jbo.2023.100482
Descripción
Sumario:With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and young adults. It is not a frequent tumor but is the second most common bone malignancy in children. It has a 5-year survival rate of 65–75%; however, it has a poor prognosis when it relapses in patients. A genomic profile of this tumor can potentially help identify poor prognosis patients earlier and guide their treatment. A systematic review of the articles concerning genetic biomarkers in Ewing sarcoma was conducted using the Google Scholar, Cochrane, and PubMed database. There were 71 articles discovered. Numerous diagnostic, prognostic, and predictive biomarkers were found. However, more research is necessary to confirm the role of some of the mentioned biomarkers. .

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