Molecular and biologic biomarkers of Ewing sarcoma: A systematic review

With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and young adults. It is not a frequent tumor but is the second most common bone malignancy in children. It has a 5-year survival rate of 65–75%; however, it has a poor prognosis when it relapses in patients. A genomic...

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Autores principales: Daher, Mohammad, Zalaquett, Ziad, Chalhoub, Ralph, Abi Farraj, Sami, Abdo, Majd, Sebaaly, Amer, Kourie, Hampig-Raphaël, Ghanem, Ismat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173001/
https://www.ncbi.nlm.nih.gov/pubmed/37180735
http://dx.doi.org/10.1016/j.jbo.2023.100482
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author Daher, Mohammad
Zalaquett, Ziad
Chalhoub, Ralph
Abi Farraj, Sami
Abdo, Majd
Sebaaly, Amer
Kourie, Hampig-Raphaël
Ghanem, Ismat
author_facet Daher, Mohammad
Zalaquett, Ziad
Chalhoub, Ralph
Abi Farraj, Sami
Abdo, Majd
Sebaaly, Amer
Kourie, Hampig-Raphaël
Ghanem, Ismat
author_sort Daher, Mohammad
collection PubMed
description With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and young adults. It is not a frequent tumor but is the second most common bone malignancy in children. It has a 5-year survival rate of 65–75%; however, it has a poor prognosis when it relapses in patients. A genomic profile of this tumor can potentially help identify poor prognosis patients earlier and guide their treatment. A systematic review of the articles concerning genetic biomarkers in Ewing sarcoma was conducted using the Google Scholar, Cochrane, and PubMed database. There were 71 articles discovered. Numerous diagnostic, prognostic, and predictive biomarkers were found. However, more research is necessary to confirm the role of some of the mentioned biomarkers. .
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spelling pubmed-101730012023-05-12 Molecular and biologic biomarkers of Ewing sarcoma: A systematic review Daher, Mohammad Zalaquett, Ziad Chalhoub, Ralph Abi Farraj, Sami Abdo, Majd Sebaaly, Amer Kourie, Hampig-Raphaël Ghanem, Ismat J Bone Oncol Review Article With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and young adults. It is not a frequent tumor but is the second most common bone malignancy in children. It has a 5-year survival rate of 65–75%; however, it has a poor prognosis when it relapses in patients. A genomic profile of this tumor can potentially help identify poor prognosis patients earlier and guide their treatment. A systematic review of the articles concerning genetic biomarkers in Ewing sarcoma was conducted using the Google Scholar, Cochrane, and PubMed database. There were 71 articles discovered. Numerous diagnostic, prognostic, and predictive biomarkers were found. However, more research is necessary to confirm the role of some of the mentioned biomarkers. . Elsevier 2023-04-26 /pmc/articles/PMC10173001/ /pubmed/37180735 http://dx.doi.org/10.1016/j.jbo.2023.100482 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Daher, Mohammad
Zalaquett, Ziad
Chalhoub, Ralph
Abi Farraj, Sami
Abdo, Majd
Sebaaly, Amer
Kourie, Hampig-Raphaël
Ghanem, Ismat
Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
title Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
title_full Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
title_fullStr Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
title_full_unstemmed Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
title_short Molecular and biologic biomarkers of Ewing sarcoma: A systematic review
title_sort molecular and biologic biomarkers of ewing sarcoma: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173001/
https://www.ncbi.nlm.nih.gov/pubmed/37180735
http://dx.doi.org/10.1016/j.jbo.2023.100482
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