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ML Flow serological test: complementary tool in leprosy()

BACKGROUND: The evaluation of household contacts of leprosy cases allows the early diagnosis of new cases. OBJECTIVE: To associate the results of the ML Flow test with the clinical characteristics of leprosy cases and to verify their positivity in household contacts, in addition to describing the ep...

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Autores principales: Montanha, Janaína Olher Martins, Nardi, Susilene Maria Tonelli, Binhardi, Fernanda Modesto Tolentino, Pedro, Heloisa da Silveira Paro, Santi, Milena Polotto de, Paschoal, Vânia Del Arco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173075/
https://www.ncbi.nlm.nih.gov/pubmed/36890048
http://dx.doi.org/10.1016/j.abd.2022.05.005
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author Montanha, Janaína Olher Martins
Nardi, Susilene Maria Tonelli
Binhardi, Fernanda Modesto Tolentino
Pedro, Heloisa da Silveira Paro
Santi, Milena Polotto de
Paschoal, Vânia Del Arco
author_facet Montanha, Janaína Olher Martins
Nardi, Susilene Maria Tonelli
Binhardi, Fernanda Modesto Tolentino
Pedro, Heloisa da Silveira Paro
Santi, Milena Polotto de
Paschoal, Vânia Del Arco
author_sort Montanha, Janaína Olher Martins
collection PubMed
description BACKGROUND: The evaluation of household contacts of leprosy cases allows the early diagnosis of new cases. OBJECTIVE: To associate the results of the ML Flow test with the clinical characteristics of leprosy cases and to verify their positivity in household contacts, in addition to describing the epidemiological profile of both. METHODS: Prospective study with patients diagnosed over the course of one year (n = 26), without prior treatment, and their household contacts (n = 44) in six municipalities in northwestern São Paulo, Brazil. RESULTS: There was a predominance of men among the leprosy cases, of 61.5% (16/26); 77% (20/26) were over 35 years old; 86.4% (22/26) were multibacillary; 61.5% (16/26) had a positive bacilloscopy; and 65.4% (17/26) had no physical disability. The ML Flow test was positive in 53.8% (14/26) of the leprosy cases and was associated with those who had a positive bacilloscopy and were diagnosed as multibacillary (p-value <0.05). Among the household contacts, 52.3% (23/44) were women and aged over 35 years; 81.8% (36/44) had been vaccinated with BCG ‒ Bacillus Calmette-Guérin. The ML Flow test was positive in 27.3% (12/44) of household contacts, all of whom lived with multibacillary cases; seven lived with positive bacilloscopy cases and six with consanguineous cases. STUDY LIMITATIONS: Difficulty in convincing the contacts to undergo the evaluation and collection of the clinical sample. CONCLUSION: The ML Flow test, when positive in household contacts, can help the identification of cases that require more attention by the health team, as it indicates a predisposition to disease development, especially when they are household contacts of multibacillary cases, with positive bacilloscopy and consanguineous. The ML Flow test also helps in the correct clinical classification of the leprosy cases.
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spelling pubmed-101730752023-05-12 ML Flow serological test: complementary tool in leprosy() Montanha, Janaína Olher Martins Nardi, Susilene Maria Tonelli Binhardi, Fernanda Modesto Tolentino Pedro, Heloisa da Silveira Paro Santi, Milena Polotto de Paschoal, Vânia Del Arco An Bras Dermatol Original Article BACKGROUND: The evaluation of household contacts of leprosy cases allows the early diagnosis of new cases. OBJECTIVE: To associate the results of the ML Flow test with the clinical characteristics of leprosy cases and to verify their positivity in household contacts, in addition to describing the epidemiological profile of both. METHODS: Prospective study with patients diagnosed over the course of one year (n = 26), without prior treatment, and their household contacts (n = 44) in six municipalities in northwestern São Paulo, Brazil. RESULTS: There was a predominance of men among the leprosy cases, of 61.5% (16/26); 77% (20/26) were over 35 years old; 86.4% (22/26) were multibacillary; 61.5% (16/26) had a positive bacilloscopy; and 65.4% (17/26) had no physical disability. The ML Flow test was positive in 53.8% (14/26) of the leprosy cases and was associated with those who had a positive bacilloscopy and were diagnosed as multibacillary (p-value <0.05). Among the household contacts, 52.3% (23/44) were women and aged over 35 years; 81.8% (36/44) had been vaccinated with BCG ‒ Bacillus Calmette-Guérin. The ML Flow test was positive in 27.3% (12/44) of household contacts, all of whom lived with multibacillary cases; seven lived with positive bacilloscopy cases and six with consanguineous cases. STUDY LIMITATIONS: Difficulty in convincing the contacts to undergo the evaluation and collection of the clinical sample. CONCLUSION: The ML Flow test, when positive in household contacts, can help the identification of cases that require more attention by the health team, as it indicates a predisposition to disease development, especially when they are household contacts of multibacillary cases, with positive bacilloscopy and consanguineous. The ML Flow test also helps in the correct clinical classification of the leprosy cases. Sociedade Brasileira de Dermatologia 2023 2023-03-06 /pmc/articles/PMC10173075/ /pubmed/36890048 http://dx.doi.org/10.1016/j.abd.2022.05.005 Text en © 2023 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Montanha, Janaína Olher Martins
Nardi, Susilene Maria Tonelli
Binhardi, Fernanda Modesto Tolentino
Pedro, Heloisa da Silveira Paro
Santi, Milena Polotto de
Paschoal, Vânia Del Arco
ML Flow serological test: complementary tool in leprosy()
title ML Flow serological test: complementary tool in leprosy()
title_full ML Flow serological test: complementary tool in leprosy()
title_fullStr ML Flow serological test: complementary tool in leprosy()
title_full_unstemmed ML Flow serological test: complementary tool in leprosy()
title_short ML Flow serological test: complementary tool in leprosy()
title_sort ml flow serological test: complementary tool in leprosy()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173075/
https://www.ncbi.nlm.nih.gov/pubmed/36890048
http://dx.doi.org/10.1016/j.abd.2022.05.005
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