Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers

INTRODUCTION: HER2 overexpression induces cancer aggression and frequent recurrences in many solid tumors. Because HER2 overproduction is generally followed by gene amplification, inhibition of protein–protein interaction (PPI) between transcriptional factor ELF3 and its coactivator MED23 has been c...

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Detalles Bibliográficos
Autores principales: Hwang, Soo-Yeon, Park, Seojeong, Jo, Hyunji, Hee Seo, Seung, Jeon, Kyung-Hwa, Kim, Seojeong, Jung, Ah-Reum, Song, Chanju, Ahn, Misun, Yeon Kwak, Soo, Lee, Hwa-Jong, Uesugi, Motonari, Na, Younghwa, Kwon, Youngjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173165/
https://www.ncbi.nlm.nih.gov/pubmed/35963541
http://dx.doi.org/10.1016/j.jare.2022.08.003

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