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Advanced 3D dynamic culture system with transforming growth factor-β3 enhances production of potent extracellular vesicles with modified protein cargoes via upregulation of TGF-β signaling

INTRODUCTION: Mesenchymal stromal cells (MSCs) release extracellular vesicles (MSC-EVs) containing various cargoes. Although MSC-EVs show significant therapeutic effects, the low production of EVs in MSCs hinders MSC-EV-mediated therapeutic development. OBJECTIVES: Here, we developed an advanced thr...

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Detalles Bibliográficos
Autores principales:	Min Lim, Kyung, Kim, Sehee, Yeom, Jeonghun, Choi, Yujin, Lee, Yoonjoo, An, Jongyub, Gil, Minchan, Abdal Dayem, Ahmed, Kim, Kyeongseok, Kang, Geun-Ho, Kim, Aram, Hong, Kwonho, Kim, Kyunggon, Cho, Ssang-Goo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173176/ https://www.ncbi.nlm.nih.gov/pubmed/36130685 http://dx.doi.org/10.1016/j.jare.2022.09.005

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