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Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCε-Stat3 pathway

INTRODUCTION: The anti-cancer medication doxorubicin (Dox) is largely restricted in clinical usage due to its significant cardiotoxicity. The only medication approved by the FDA for Dox-induced cardiotoxicity is dexrazoxane, while it may reduce the sensitivity of cancer cells to chemotherapy and is...

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Detalles Bibliográficos
Autores principales:	Ding, Mingge, Shi, Rui, Fu, Feng, Li, Man, De, Dema, Du, Yanyan, Li, Zongfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173194/ https://www.ncbi.nlm.nih.gov/pubmed/35842187 http://dx.doi.org/10.1016/j.jare.2022.07.002

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