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Applications of synthetic biology in medical and pharmaceutical fields

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological building blocks and to develop various genomic/metabolic engineering tools and approach...

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Autores principales: Yan, Xu, Liu, Xu, Zhao, Cuihuan, Chen, Guo-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173249/
https://www.ncbi.nlm.nih.gov/pubmed/37169742
http://dx.doi.org/10.1038/s41392-023-01440-5
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author Yan, Xu
Liu, Xu
Zhao, Cuihuan
Chen, Guo-Qiang
author_facet Yan, Xu
Liu, Xu
Zhao, Cuihuan
Chen, Guo-Qiang
author_sort Yan, Xu
collection PubMed
description Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological building blocks and to develop various genomic/metabolic engineering tools and approaches. Medical and pharmaceutical demands have also pushed the development of synthetic biology, including integration of heterologous pathways into designer cells to efficiently produce medical agents, enhanced yields of natural products in cell growth media to equal or higher than that of the extracts from plants or fungi, constructions of novel genetic circuits for tumor targeting, controllable releases of therapeutic agents in response to specific biomarkers to fight diseases such as diabetes and cancers. Besides, new strategies are developed to treat complex immune diseases, infectious diseases and metabolic disorders that are hard to cure via traditional approaches. In general, synthetic biology brings new capabilities to medical and pharmaceutical researches. This review summarizes the timeline of synthetic biology developments, the past and present of synthetic biology for microbial productions of pharmaceutics, engineered cells equipped with synthetic DNA circuits for diagnosis and therapies, live and auto-assemblied biomaterials for medical treatments, cell-free synthetic biology in medical and pharmaceutical fields, and DNA engineering approaches with potentials for biomedical applications.
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spelling pubmed-101732492023-05-13 Applications of synthetic biology in medical and pharmaceutical fields Yan, Xu Liu, Xu Zhao, Cuihuan Chen, Guo-Qiang Signal Transduct Target Ther Review Article Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological building blocks and to develop various genomic/metabolic engineering tools and approaches. Medical and pharmaceutical demands have also pushed the development of synthetic biology, including integration of heterologous pathways into designer cells to efficiently produce medical agents, enhanced yields of natural products in cell growth media to equal or higher than that of the extracts from plants or fungi, constructions of novel genetic circuits for tumor targeting, controllable releases of therapeutic agents in response to specific biomarkers to fight diseases such as diabetes and cancers. Besides, new strategies are developed to treat complex immune diseases, infectious diseases and metabolic disorders that are hard to cure via traditional approaches. In general, synthetic biology brings new capabilities to medical and pharmaceutical researches. This review summarizes the timeline of synthetic biology developments, the past and present of synthetic biology for microbial productions of pharmaceutics, engineered cells equipped with synthetic DNA circuits for diagnosis and therapies, live and auto-assemblied biomaterials for medical treatments, cell-free synthetic biology in medical and pharmaceutical fields, and DNA engineering approaches with potentials for biomedical applications. Nature Publishing Group UK 2023-05-11 /pmc/articles/PMC10173249/ /pubmed/37169742 http://dx.doi.org/10.1038/s41392-023-01440-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Yan, Xu
Liu, Xu
Zhao, Cuihuan
Chen, Guo-Qiang
Applications of synthetic biology in medical and pharmaceutical fields
title Applications of synthetic biology in medical and pharmaceutical fields
title_full Applications of synthetic biology in medical and pharmaceutical fields
title_fullStr Applications of synthetic biology in medical and pharmaceutical fields
title_full_unstemmed Applications of synthetic biology in medical and pharmaceutical fields
title_short Applications of synthetic biology in medical and pharmaceutical fields
title_sort applications of synthetic biology in medical and pharmaceutical fields
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173249/
https://www.ncbi.nlm.nih.gov/pubmed/37169742
http://dx.doi.org/10.1038/s41392-023-01440-5
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