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Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis

PURPOSE: Vitamin D deficiency is frequent in patients with multiple myeloma (MM), however, its prognostic relevance in MM was rather inconclusive. We first investigated the association of vitamin D deficiency with abnormal bone and lipid metabolism in newly diagnosed multiple myeloma (NDMM), and nex...

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Autores principales: Bao, Li, Wang, Yu-tong, Lu, Min-qiu, Chu, Bin, Shi, Lei, Gao, Shan, Fang, Li-juan, Xiang, Qiu-qing, Ding, Yue-hua, Liu, Xi, Zhao, Xin, Wang, Meng-zhen, Chen, Yuan, Hu, Wei-kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173308/
https://www.ncbi.nlm.nih.gov/pubmed/37181039
http://dx.doi.org/10.3389/fendo.2023.1157969
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author Bao, Li
Wang, Yu-tong
Lu, Min-qiu
Chu, Bin
Shi, Lei
Gao, Shan
Fang, Li-juan
Xiang, Qiu-qing
Ding, Yue-hua
Liu, Xi
Zhao, Xin
Wang, Meng-zhen
Chen, Yuan
Hu, Wei-kai
author_facet Bao, Li
Wang, Yu-tong
Lu, Min-qiu
Chu, Bin
Shi, Lei
Gao, Shan
Fang, Li-juan
Xiang, Qiu-qing
Ding, Yue-hua
Liu, Xi
Zhao, Xin
Wang, Meng-zhen
Chen, Yuan
Hu, Wei-kai
author_sort Bao, Li
collection PubMed
description PURPOSE: Vitamin D deficiency is frequent in patients with multiple myeloma (MM), however, its prognostic relevance in MM was rather inconclusive. We first investigated the association of vitamin D deficiency with abnormal bone and lipid metabolism in newly diagnosed multiple myeloma (NDMM), and next assessed the impact of serum ratio of vitamin D to carboxy-terminal telopeptide of type I collagen (β-CTX) on progression-free survival (PFS) and overall free survival (OS) in patients with NDMM. METHODS: The data of 431 consecutive patients with NDMM at Beijing Jishuitan Hospital from September 2013 to December 2022 were collected and retrospectively reviewed through our electronic medical record system. The measurement of 25-hydroxyvitamin D in the blood is an indicator of an individual’s overall vitamin D status. RESULTS: The serum levels of vitamin D were negatively correlated with β-CTX in NDMM patients. Of note, positive correlation between vitamin D and cholesterol levels in the serum was found in this study. The cohort (n = 431) was divided into two groups based on the serum ratio of vitamin D to β-CTX. Compared to the group with a higher vitamin D to β-CTX ratio, the group with a lower vitamin D to β-CTX ratio (n = 257, 60%) exhibited hypocholesterolemia, inferior PFS and OS, along with increased cases of ISS stage-III and R-ISS stage-III, a higher number of plasma cells in the bone marrow, and elevated serum calcium levels. Consistent with this, multivariate analysis confirmed that the vitamin D to β-CTX ratio was an independent unfavorable indicator for survival in NDMM patients. CONCLUSION: Our data demonstrated the ratio of vitamin D to β-CTX in the serum is a unique biomarker for NDMM patients to identify the high-risk cases with poor prognosis, which is superior to vitamin D itself for predicting PFS and OS in NDMM. Also, it is worth mentioning that our data on the connection between vitamin D deficiency and hypocholesterolemia might help clarify novel mechanistic aspects of myeloma development.
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spelling pubmed-101733082023-05-12 Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis Bao, Li Wang, Yu-tong Lu, Min-qiu Chu, Bin Shi, Lei Gao, Shan Fang, Li-juan Xiang, Qiu-qing Ding, Yue-hua Liu, Xi Zhao, Xin Wang, Meng-zhen Chen, Yuan Hu, Wei-kai Front Endocrinol (Lausanne) Endocrinology PURPOSE: Vitamin D deficiency is frequent in patients with multiple myeloma (MM), however, its prognostic relevance in MM was rather inconclusive. We first investigated the association of vitamin D deficiency with abnormal bone and lipid metabolism in newly diagnosed multiple myeloma (NDMM), and next assessed the impact of serum ratio of vitamin D to carboxy-terminal telopeptide of type I collagen (β-CTX) on progression-free survival (PFS) and overall free survival (OS) in patients with NDMM. METHODS: The data of 431 consecutive patients with NDMM at Beijing Jishuitan Hospital from September 2013 to December 2022 were collected and retrospectively reviewed through our electronic medical record system. The measurement of 25-hydroxyvitamin D in the blood is an indicator of an individual’s overall vitamin D status. RESULTS: The serum levels of vitamin D were negatively correlated with β-CTX in NDMM patients. Of note, positive correlation between vitamin D and cholesterol levels in the serum was found in this study. The cohort (n = 431) was divided into two groups based on the serum ratio of vitamin D to β-CTX. Compared to the group with a higher vitamin D to β-CTX ratio, the group with a lower vitamin D to β-CTX ratio (n = 257, 60%) exhibited hypocholesterolemia, inferior PFS and OS, along with increased cases of ISS stage-III and R-ISS stage-III, a higher number of plasma cells in the bone marrow, and elevated serum calcium levels. Consistent with this, multivariate analysis confirmed that the vitamin D to β-CTX ratio was an independent unfavorable indicator for survival in NDMM patients. CONCLUSION: Our data demonstrated the ratio of vitamin D to β-CTX in the serum is a unique biomarker for NDMM patients to identify the high-risk cases with poor prognosis, which is superior to vitamin D itself for predicting PFS and OS in NDMM. Also, it is worth mentioning that our data on the connection between vitamin D deficiency and hypocholesterolemia might help clarify novel mechanistic aspects of myeloma development. Frontiers Media S.A. 2023-04-27 /pmc/articles/PMC10173308/ /pubmed/37181039 http://dx.doi.org/10.3389/fendo.2023.1157969 Text en Copyright © 2023 Bao, Wang, Lu, Chu, Shi, Gao, Fang, Xiang, Ding, Liu, Zhao, Wang, Chen and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Bao, Li
Wang, Yu-tong
Lu, Min-qiu
Chu, Bin
Shi, Lei
Gao, Shan
Fang, Li-juan
Xiang, Qiu-qing
Ding, Yue-hua
Liu, Xi
Zhao, Xin
Wang, Meng-zhen
Chen, Yuan
Hu, Wei-kai
Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
title Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
title_full Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
title_fullStr Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
title_full_unstemmed Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
title_short Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
title_sort vitamin d deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173308/
https://www.ncbi.nlm.nih.gov/pubmed/37181039
http://dx.doi.org/10.3389/fendo.2023.1157969
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