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Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors

BACKGROUND: Animal diseases are a danger to livestock, businesses, and public health. This is why the public and private sectors in Africa have invested immensely in the manufacture and distribution of veterinary drugs. However, veterinary drug supply chain actors still suffer losses as a result of...

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Autores principales: Kisaka, Stevens, Tumwebaze, Frank K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173504/
https://www.ncbi.nlm.nih.gov/pubmed/37165424
http://dx.doi.org/10.1186/s40545-023-00569-6
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author Kisaka, Stevens
Tumwebaze, Frank K.
author_facet Kisaka, Stevens
Tumwebaze, Frank K.
author_sort Kisaka, Stevens
collection PubMed
description BACKGROUND: Animal diseases are a danger to livestock, businesses, and public health. This is why the public and private sectors in Africa have invested immensely in the manufacture and distribution of veterinary drugs. However, veterinary drug supply chain actors still suffer losses as a result of expiration. Besides, the way expired products are managed might pose risks to human, animal, and environmental health. This study investigated the prevalence, management of, and factors associated with the expiry of veterinary medicines in supply outlets in Central Uganda. METHODS: A cross-sectional study was conducted among owners and caretakers of veterinary drug supply outlets. Data were collected using self-administered, semi-structured questionnaires. The level of expiry was computed as “acceptable” (for levels reported as ≤ 5%) and “unacceptable” (for levels reported as ˃5%). Logistic regression was used to assess associations between the level of drug expiry and predictor variables. RESULTS: A total of 168 owners/caretakers of veterinary drug supply outlets were included in this study. The majority (148/168, 88.1%) of respondents reported having experienced expiries in their outlets. Unacceptable levels of expiry were reported in 38/168 (22.6%) of the outlets. Retail outlets accounted for the majority (34/38, 89.5%) of the unacceptable levels. Powdered drugs accounted for most expiries (106/148, 71.6%). Most expiries were for drugs supplied to outlets on credit (58/124, 46.8%) and those used to treat rare diseases (26/124, 21%). Major reasons for expiry included irrational prescription, inaccurate forecasts, overstocking, dry seasons, and stocking without considering stock-at-hand. Methods of disposal of expired drugs included throwing at pits (74/168, 44.1%); returning drugs to suppliers (51/168, 30.4%); and incineration (33/168, 19.6%). Factors associated with acceptable levels of expiry included the caretaker being female [adjusted OR = 2.9, 95% CI = 1.22–5.08]; having a procurement policy [adjusted OR = 3.9, 95% CI = 1.29–4.81] and practicing first expiry, first out [adjusted OR = 6.07, 95% CI = 4.71–8.70]. CONCLUSIONS: Veterinary drug expiries are common in Uganda, and environmentally unfriendly methods of disposal are widely used. Acquisition and use of inventory tracking technologies that support First-Expiry-First-Out principles as well as proper disposal of expired medicines are recommended.
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spelling pubmed-101735042023-05-12 Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors Kisaka, Stevens Tumwebaze, Frank K. J Pharm Policy Pract Research BACKGROUND: Animal diseases are a danger to livestock, businesses, and public health. This is why the public and private sectors in Africa have invested immensely in the manufacture and distribution of veterinary drugs. However, veterinary drug supply chain actors still suffer losses as a result of expiration. Besides, the way expired products are managed might pose risks to human, animal, and environmental health. This study investigated the prevalence, management of, and factors associated with the expiry of veterinary medicines in supply outlets in Central Uganda. METHODS: A cross-sectional study was conducted among owners and caretakers of veterinary drug supply outlets. Data were collected using self-administered, semi-structured questionnaires. The level of expiry was computed as “acceptable” (for levels reported as ≤ 5%) and “unacceptable” (for levels reported as ˃5%). Logistic regression was used to assess associations between the level of drug expiry and predictor variables. RESULTS: A total of 168 owners/caretakers of veterinary drug supply outlets were included in this study. The majority (148/168, 88.1%) of respondents reported having experienced expiries in their outlets. Unacceptable levels of expiry were reported in 38/168 (22.6%) of the outlets. Retail outlets accounted for the majority (34/38, 89.5%) of the unacceptable levels. Powdered drugs accounted for most expiries (106/148, 71.6%). Most expiries were for drugs supplied to outlets on credit (58/124, 46.8%) and those used to treat rare diseases (26/124, 21%). Major reasons for expiry included irrational prescription, inaccurate forecasts, overstocking, dry seasons, and stocking without considering stock-at-hand. Methods of disposal of expired drugs included throwing at pits (74/168, 44.1%); returning drugs to suppliers (51/168, 30.4%); and incineration (33/168, 19.6%). Factors associated with acceptable levels of expiry included the caretaker being female [adjusted OR = 2.9, 95% CI = 1.22–5.08]; having a procurement policy [adjusted OR = 3.9, 95% CI = 1.29–4.81] and practicing first expiry, first out [adjusted OR = 6.07, 95% CI = 4.71–8.70]. CONCLUSIONS: Veterinary drug expiries are common in Uganda, and environmentally unfriendly methods of disposal are widely used. Acquisition and use of inventory tracking technologies that support First-Expiry-First-Out principles as well as proper disposal of expired medicines are recommended. BioMed Central 2023-05-10 /pmc/articles/PMC10173504/ /pubmed/37165424 http://dx.doi.org/10.1186/s40545-023-00569-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kisaka, Stevens
Tumwebaze, Frank K.
Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors
title Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors
title_full Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors
title_fullStr Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors
title_full_unstemmed Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors
title_short Expiry of veterinary medicines in supply outlets in Central Uganda: prevalence, management and associated factors
title_sort expiry of veterinary medicines in supply outlets in central uganda: prevalence, management and associated factors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173504/
https://www.ncbi.nlm.nih.gov/pubmed/37165424
http://dx.doi.org/10.1186/s40545-023-00569-6
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