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Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn’s disease: a multi-omics Mendelian randomization study

BACKGROUND: Oxidative stress (OS) is a key pathophysiological mechanism in Crohn’s disease (CD). OS-related genes can be affected by environmental factors, intestinal inflammation, gut microbiota, and epigenetic changes. However, the role of OS as a potential CD etiological factor or triggering fact...

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Detalles Bibliográficos
Autores principales:	Xu, Shu, Li, Xiaozhi, Zhang, Shenghong, Qi, Cancan, Zhang, Zhenhua, Ma, Ruiqi, Xiang, Liyuan, Chen, Lianmin, Zhu, Yijun, Tang, Ce, Bourgonje, Arno R., Li, Miaoxin, He, Yao, Zeng, Zhirong, Hu, Shixian, Feng, Rui, Chen, Minhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173549/ https://www.ncbi.nlm.nih.gov/pubmed/37170220 http://dx.doi.org/10.1186/s12916-023-02878-8

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