Loss of CpG island immunity to DNA methylation induced by mutation

The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715–731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern can be t...

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Autores principales: Horsthemke, Bernhard, Bird, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173581/
https://www.ncbi.nlm.nih.gov/pubmed/37170330
http://dx.doi.org/10.1186/s13072-023-00488-5
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author Horsthemke, Bernhard
Bird, Adrian
author_facet Horsthemke, Bernhard
Bird, Adrian
author_sort Horsthemke, Bernhard
collection PubMed
description The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715–731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern can be transmitted across generations, even after removal of the foreign DNA. These results were interpreted as evidence for transgenerational inheritance of acquired DNA methylation patterns. Here, we discuss several interpretational issues raised by this study and consider alternative explanations.
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spelling pubmed-101735812023-05-12 Loss of CpG island immunity to DNA methylation induced by mutation Horsthemke, Bernhard Bird, Adrian Epigenetics Chromatin Comment The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715–731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI) can induce DNA methylation of the CGI and that this aberrant methylation pattern can be transmitted across generations, even after removal of the foreign DNA. These results were interpreted as evidence for transgenerational inheritance of acquired DNA methylation patterns. Here, we discuss several interpretational issues raised by this study and consider alternative explanations. BioMed Central 2023-05-11 /pmc/articles/PMC10173581/ /pubmed/37170330 http://dx.doi.org/10.1186/s13072-023-00488-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Comment
Horsthemke, Bernhard
Bird, Adrian
Loss of CpG island immunity to DNA methylation induced by mutation
title Loss of CpG island immunity to DNA methylation induced by mutation
title_full Loss of CpG island immunity to DNA methylation induced by mutation
title_fullStr Loss of CpG island immunity to DNA methylation induced by mutation
title_full_unstemmed Loss of CpG island immunity to DNA methylation induced by mutation
title_short Loss of CpG island immunity to DNA methylation induced by mutation
title_sort loss of cpg island immunity to dna methylation induced by mutation
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173581/
https://www.ncbi.nlm.nih.gov/pubmed/37170330
http://dx.doi.org/10.1186/s13072-023-00488-5
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