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Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

BACKGROUND: Transferrin receptor 1 (TfR1) mediated brain delivery of antibodies could become important for increasing the efficacy of emerging immunotherapies in Alzheimer's disease (AD). However, age, dose, binding to TfR1 on blood cells, and pathology could influence the TfR1-mediated transcy...

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Detalles Bibliográficos
Autores principales:	Faresjö, Rebecca, Sehlin, Dag, Syvänen, Stina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173660/ https://www.ncbi.nlm.nih.gov/pubmed/37170266 http://dx.doi.org/10.1186/s12987-023-00435-2

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